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Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement

  • Assisted Reproduction Technologies
  • Published:
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Abstract

Purpose

To investigate the impact of late follicular phase serum estradiol (E2) levels on implantation and pregnancy outcomes of cleavage stage cryopreserved/thawed embryos transferred in programmed cycles with exogenous hormonal replacement.

Methods

Retrospective cohort analysis of IVF patients with transfer of cryopreserved-thawed day-3 embryos in E2 and progesterone (P4) supplemented cycles (n = 208 cycles). Main outcome measures: implantation and pregnancy rates according to late follicular phase serum E2 levels and early secretory phase E2/P4 ratios.

Results

Logistic regression performed for embryo implantation and for pregnancy outcome in relation to E2 (day 15), P4 (day 15 and 16), before (crude analysis) and after adjustment (adjusted analysis) for baseline characteristics (including age, BMI, serum basal cycle day 3 FSH levels, embryo quality, endometrial lining thickness) showed no significant association. Similarly, ROC analysis showed no impact of cycle day 16 E2/P4 ratio.

Conclusions

Neither late follicular phase serum E2 nor the early E2/P4 ratio were able to predict implantation or pregnancy outcome of day-3 cryopreserved-thawed embryos transferred in artificially programmed cycles.

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Authors and Affiliations

  1. The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA, 23507, USA

    Silvina Bocca, Elvira Bondía Real, Susanna Lynch, Laurel Stadtmauer, Jacob Mayer & Sergio Oehninger

  2. Graduate Program in Public Health, Eastern Virginia Medical School, Norfolk, VA, 23507, USA

    Hind Beydoun

Authors
  1. Silvina Bocca
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  2. Elvira Bondía Real
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  3. Susanna Lynch
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  4. Laurel Stadtmauer
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  5. Hind Beydoun
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  6. Jacob Mayer
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  7. Sergio Oehninger
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Corresponding author

Correspondence to Sergio Oehninger.

Additional information

Capsule This retrospective cohort study showed that neither late follicular phase serum E2 nor the early E2/P4 ratio were able to predict implantation or pregnancy outcome of day-3 cryopreserved-thawed embryos transferred in artificially programmed cycles.

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Bocca, S., Real, E.B., Lynch, S. et al. Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement. J Assist Reprod Genet 32, 395–400 (2015). https://doi.org/10.1007/s10815-014-0402-1

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  • DOI: https://doi.org/10.1007/s10815-014-0402-1

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