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Anti-Müllerian hormone levels as a predictor of the pregnancy rate in women of advanced reproductive age

  • Assisted Reproduction Technologies
  • Published:
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Abstract

Purpose

To investigate whether serum anti-müllerian hormone (AMH), follicle stimulating hormone (FSH), or antral follicle count (AFC) are predictive for clinical pregnancy in women who underwent IVF cycles at the age of 35 and older

Methods

A total of 240 consecutive women who underwent IVF cycles at the age of 35 and older were enrolled in this crsoss- sectional study. Pregnant and nonpregnant women were compared.

Results

The median AMH level of pregnant women was higher than non-pregnant women [3.20 (0.63–9.60) vs 1.15 (0.01–14.90) ng/ml, p < 0.001]. On logistic regression analysis, AMH was an independent predictor of clinical pregnancy rate (CPR) (OR 1.353; 95 % CI 1.141–1.605; P < 0.001). After controlling for the other independent variables (the number of retrieved oocytes, AFC and age), the significant association between AMH and clinical pregnancy rate remained strong (OR 1.677; 95 % CI 1.216–2.311; p = 0.002) on multivariate logistic regression analysis.

Conclusions

AMH is an effective measure of quantitative ovarian reserve and it can predict ovarian response to controlled stimulation for advanced age women. The CPR tends to increase as AMH increases.

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Acknowledgments

We would like to thank Hulya Senol, Naciye Erol, Burcu Dincgez Cakmak, Sukru Cebi and Mutlu Tezel for their sincere support data collection and technical assistance.

Declaration of interest

All authors have nothing to disclose. There have not been any financialsupport.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Sezai Sahmay, Mahmut Oncul, Abdullah Tuten, Abdullah Serdar Acıkgoz & Ismail Cepni

  2. Department of Obstetrics and Gynecology, Mersin Public Hospital, Mersin, Turkey

    Abdullah Tok

  3. Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, Istanbul University, Kizilelma Caddesi, No: 35/1, Fatih, 34300, Istanbul, Turkey

    Mahmut Oncul

Authors
  1. Sezai Sahmay
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  2. Mahmut Oncul
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  3. Abdullah Tuten
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  4. Abdullah Tok
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  5. Abdullah Serdar Acıkgoz
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  6. Ismail Cepni
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Corresponding author

Correspondence to Mahmut Oncul.

Additional information

Capsule The AMH levels are more useful than FSH and AFC for the prediction of clinical pregnancy rate in women who underwent IVF cycles at the age of 35 and older.

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Sahmay, S., Oncul, M., Tuten, A. et al. Anti-Müllerian hormone levels as a predictor of the pregnancy rate in women of advanced reproductive age. J Assist Reprod Genet 31, 1469–1474 (2014). https://doi.org/10.1007/s10815-014-0324-y

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  • DOI: https://doi.org/10.1007/s10815-014-0324-y

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