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Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters

  • Assisted Reproduction Technologies
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Abstract

Purpose

To examine the impact on development of derived embryos from smooth endoplasmic reticulum clusters (SERC) in human metaphase II (MII) oocytes.

Methods

Retrospective analysis at Kyono ART Clinic. Comparison of embryological development, pregnancy, live birth and fetal malformation between oocytes with SERC (the SERC(+) group) and those without (the SERC(−) group) in 2,158 patients (3,758 cycles) after ICSI.

Results

Fertilization and implantation rate were significantly lower in SERC(+) MII oocytes than in SERC(−) MII oocytes. After the transfer of fresh and vitrified embryos derived from SERC(+) oocytes, 14 pregnancies resulted in 14 healthy babies, including 2 from fresh embryo transfer (ET) and 12 from vitrified-warmed ET, with no malformations.

Conclusion(s)

The presence of SERC in MII oocytes was associated with significantly lower fertilization rates and implantation rates than seen in SERC(−) MII oocytes within SERC (+) cycles. However, SERC had no impact on post-implantation development as well as neonatal outcome.

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Acknowledgments

The author would like to thank Ms. Y. Nakano, Ms. T. Kuzuno and Ms. C. Onuma for assistance in layout.

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Authors and Affiliations

  1. Kyono ART Clinic, Mitsui-Seimei, Sendai Honcho Bl, 3F, 1-1-1 Honcho, Aoba-ku, Sendai, Miyagi, 980-0014, Japan

    Hiromitsu Hattori, Yusuke Nakamura, Yukiko Nakajo & Koichi Kyono

  2. The Institute for Advanced Reproductive Medical Technology, 909-21 Ishii, Maebashi, Gunma, 371-0105, Japan

    Yasuhisa Araki

  3. Kyono ART Clinic Takanawa, Takanawa Court 5F, 3-13-1 Takanawa, Minato-ku, Tokyo, 108-0074, Japan

    Koichi Kyono

Authors
  1. Hiromitsu Hattori
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  2. Yusuke Nakamura
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  3. Yukiko Nakajo
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  4. Yasuhisa Araki
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  5. Koichi Kyono
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Corresponding author

Correspondence to Koichi Kyono.

Additional information

Capsule To evaluate the impact of smooth endoplasmic reticulum clusters (SERCs) in human metaphase II (MII) oocytes on embryo development, clinical pregnancy rate and miscarriage rate.

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Hattori, H., Nakamura, Y., Nakajo, Y. et al. Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters. J Assist Reprod Genet 31, 1461–1467 (2014). https://doi.org/10.1007/s10815-014-0323-z

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  • DOI: https://doi.org/10.1007/s10815-014-0323-z

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