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Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

This study aims to explore possible associations between polymorphisms of common SNP rs1136410 and rS1805405 in PARP1 gene and male infertility with spermatogenesis impairment.

Methods

The polymorphic distributions of SNP rs1136410 and rS1805405 were investigated by polymerase chain reaction and restriction fragment length polymorphism analysis in a Chinese cohort including 371 infertile patients with idiopathic azoospermia or oligospermia and 231 controls.

Results

Significant differences in the frequencies of allele and genotype of SNP rs1136410 were observed between patients with oligospermia and controls. The allele C (46.3 % vs. 36.4 %, P = 0.003) and genotype CC (22.6 % vs. 13.4 %, P = 0.014) significantly increased, whereas genotype TT (30 % vs. 40.7 %, P = 0.021) significantly decreased in patients with oligospermia compared with controls at this SNP locus.

Conclusions

These results indicated that genotype CC of SNP rs1136410 may increase the risk of oligosoermia and genotype TT of rs1136410 may have some protective effect from oligospermia, suggesting that the polymorphism of SNP rs1136410 in PARP1 gene may modify the susceptibility to male infertility with oligospermia.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Genetics, College of Agriculture and Biology, Dali University, Dali, Yunnan, 671003, China

    Hui Chen, Xiao-Ying Pu & Zhou-Cun A

  2. College of Basic Medicine, Dali University, Dali, 671000, China

    Hui Chen

  3. Department of Reproductive Medicine, Affiliated Hospital of Dali University, Dali, 671000, China

    Ruo-Peng Zhang

Authors
  1. Hui Chen
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  2. Xiao-Ying Pu
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  3. Ruo-Peng Zhang
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  4. Zhou-Cun A
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Corresponding author

Correspondence to Zhou-Cun A.

Additional information

Capsule The results of this study suggested that polymorphism of SNP rs1136410 in PARP1 gene may modify the susceptibility to male infertility with oligospermia.

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Chen, H., Pu, XY., Zhang, RP. et al. Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. J Assist Reprod Genet 31, 1391–1395 (2014). https://doi.org/10.1007/s10815-014-0311-3

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  • DOI: https://doi.org/10.1007/s10815-014-0311-3

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