Journal of Assisted Reproduction and Genetics

, Volume 31, Issue 9, pp 1147–1153 | Cite as

Predictive value of postwashed total progressively motile sperm count using CASA estimates in 6871 non-donor intrauterine insemination cycles

  • Orkun Tan
  • Thoa Ha
  • Bruce R. Carr
  • Paul Nakonezny
  • Kathleen M. Doody
  • Kevin J. Doody
Assisted Reproduction Technologies



To determine whether postwashed total progressively motile sperm count (TPMSC) obtained by CASA estimates could predict positive pregnancy test result in non-donor IUI cycles.


Six thousand eight hundred and seventy one (6,871) IUI cycles with non-donor semen were retrospectively analyzed. Patient, cycle characteristics and prewashed and postwashed semen parameters were included in analysis. The main outcome measure was the positive pregnancy test result.


The pregnancy rate per cycle (PR/cycle) when postwashed TPMSC is between 0–0.5 million, 0.51–1 million, 1.01–5 million, 5.01–10 million and greater than 10 million were 8.1 % (42/520), 14.4 % (41/285), 16.1 % (237/1,469), 18.4 % (193/1,046) and 18.8 % (668/3,551) respectively. The predicted odd of positive pregnancy result is statistically significantly higher when TPMSC is >0.51 million compared to the TPMSC of <0.51 million (OR = 1.68, 95 % CI: 1.04–2.71). The predicted odd of positive pregnancy result is greatest when TPMSC is at least 5 million (OR = 2, 95 % CI: 1.38 to 2.9).


TPMSC is an independent predictor of pregnancy test result and TPMSC of half million or greater is adequate to achieve statistically similar pregnancy test results after non-donor IUI cycles.


Intrauterine insemination Computer assisted sperm analysis Pregnancy Semen analysis 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Orkun Tan
    • 1
    • 2
  • Thoa Ha
    • 1
  • Bruce R. Carr
    • 1
  • Paul Nakonezny
    • 3
  • Kathleen M. Doody
    • 4
  • Kevin J. Doody
    • 1
    • 4
  1. 1.Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and GynecologyUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.ReproMed Fertility CenterDallasUSA
  3. 3.Department of Clinical Sciences, Division of BiostatisticsUniversity of Texas Southwestern Medical CenterDallasUSA
  4. 4.Center for Assisted ReproductionBedfordUSA

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