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Neonatal outcome of early rescue ICSI and ICSI with ejaculated sperm

  • Assisted Reproduction Technologies
  • Published:
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Abstract

Purpose

To evaluate the impact of early rescue ICSI on neonatal outcome.

Methods

This retrospective study compared the neonatal outcome of early rescue ICSI and ICSI with ejaculated sperm, including 233 children who were conceived after early rescue ICSI and a control group of 906 children who were conceived after ICSI with ejaculated sperm, and all of the children had a gestational age of 20 weeks or more. The numbers of live and stillbirths, perinatal deaths, prematurity, birthweights and birth defects of the children were compared.

Results

Children in the early rescue ICSI group showed no increased risk of stillbirths, perinatal death or birth defects. Those children also did not differ from those of the ICSI with ejaculated sperm group in gender rate, birthweight, gestational age or prematurity.

Conclusions

Early rescue ICSI did not increase the adverse effect on the neonatal outcome when compared to that of ICSI with ejaculated sperm.

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Acknowledgments

This work was supported by the Health Industry Special (No. 201002013), National Natural Science Foundation of China (No. 81070492, No. 81170570, and No. 81370683), a Special Grant for Principal Investigators from the Health Department of Jiangsu Province (No. LJ201102, and No. RC2011005), and the Key Project supported by Medical Science and technology development Foundation, Nanjing Department of Health (YKK12054).

Competing interest

There is no conflict of interest in this manuscript.

Authors’ contributions

Haixiang Sun devised the idea for this project. Linjun Chen and Zhipeng Xu wrote the manuscript. Ningyuan Zhang, Bin Wang, Hua Chen and Shanshan Wang acquired and analyzed the data. All authors critically reviewed the article.

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Authors and Affiliations

  1. Reproductive Medicine Center, Drum Tower Hospital Affiliated to Nanjing University Medical College, Nanjing, Jiangsu, 210008, China

    Linjun Chen, Zhipeng Xu, Ningyuan Zhang, Bin Wang, Hua Chen, Shanshan Wang & Haixiang Sun

Authors
  1. Linjun Chen
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  2. Zhipeng Xu
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  3. Ningyuan Zhang
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  4. Bin Wang
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  5. Hua Chen
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  6. Shanshan Wang
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  7. Haixiang Sun
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Corresponding author

Correspondence to Haixiang Sun.

Additional information

Capsule Early rescue ICSI did not increase the adverse effect on the neonatal outcome.

Linjun Chen and Zhipeng Xu contributed equally to this work.

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Chen, L., Xu, Z., Zhang, N. et al. Neonatal outcome of early rescue ICSI and ICSI with ejaculated sperm. J Assist Reprod Genet 31, 823–828 (2014). https://doi.org/10.1007/s10815-014-0245-9

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  • DOI: https://doi.org/10.1007/s10815-014-0245-9

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