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The Asn680Ser polymorphism of the follicle stimulating hormone receptor gene and ovarian cancer risk: a meta-analysis

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study was to conduct a meta-analysis to assess the association between FSHR Asn680Ser polymorphism and ovarian cancer susceptibility.

Methods

A literature search was conducted in PubMed, Embase and the China National Knowledge Infrastructure (CNKI) for all relevant studies published up to September 2013. The pooled odds ratios (ORs) with the corresponding 95 % confidence intervals (95 % CIs) were calculated to evaluate the association.

Results

Four case–control studies including 474 ovarian cancer cases and 659 controls met the inclusion criteria. The pooled analyses showed that FSHR Asn680Ser polymorphism was associated with the risk of ovarian cancer (Ser vs Asn: OR = 1.295, 95 % CI 1.057–1.498, P = 0.01; Ser/Ser + Asn/Ser vs Asn/Asn: OR = 1.611, 95 % CI 1.027–2.528, P = 0.038). Subgroup analyses by ethnicity (Caucasian and Asian) further revealed significant associations among Asians (Ser vs Asn: OR = 1.386, 95 % CI 1.066–1.802, P = 0.015; Ser/Ser + Asn/Ser vs Asn/Asn: OR = 1.893, 95 % CI 1.329–2.689, P = 0.000) but not Caucasians. There was no obvious risk of publication bias.

Conclusions

The meta-analysis suggests that FSHR Asn680Ser polymorphism may be a risk factor for ovarian cancer in Asians. Due to the limited quantity of the included studies, further studies are needed to validate the above conclusions.

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Conflicts of interest

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Authors and Affiliations

  1. Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China

    Xue Qin, Liping Ma, Shi Yang, Jiangyang Zhao, Jian Wang, Taijie Li, Yu He, Qiliu Peng, Yan Deng & Shan Li

  2. Guangxi University of Chinese Medicine, Nanning, Guangxi, China

    Siyuan Chen

  3. Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China

    Yantong Xie

  4. Department of Obstetrics and Gynecology and Reproductive Center, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China

    Aiping Qin

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  1. Xue Qin
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  2. Liping Ma
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  3. Shi Yang
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  11. Yan Deng
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  12. Shan Li
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  13. Aiping Qin
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Correspondence to Shan Li or Aiping Qin.

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Capsule

It has been speculated that FSHR Asn680Ser polymorphism is probably involved in susceptibility to cancer. This meta-analysis found that FSHR Asn680Ser polymorphism may be a risk factor for ovarian cancer in Asians.

Xue Qin, Liping Ma and Shi Yang contributed equally to this study and should be considered as co-frist authors.

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Qin, X., Ma, L., Yang, S. et al. The Asn680Ser polymorphism of the follicle stimulating hormone receptor gene and ovarian cancer risk: a meta-analysis. J Assist Reprod Genet 31, 683–688 (2014). https://doi.org/10.1007/s10815-014-0218-z

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  • DOI: https://doi.org/10.1007/s10815-014-0218-z

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