Administration of DHEA augments progesterone production in a woman with low ovarian reserve being transplanted with cryopreserved ovarian tissue

  • Susanne Strauss
  • Tine Greve
  • Erik Ernst
  • Matthiaos Fraidakis
  • Jurgis Gedis Grudzinskas
  • Claus Yding Andersen
Fertility Preservation


In recent years cryopreservation of ovarian tissue prior to potentially gonadotoxic treatment for malignant disease has proved to be an option for preservation of the reproductive function including fertility [1]. Following successful cancer treatment women have chosen to have transplantation of their frozen-thawed tissue if ovarian failure occurred as a consequence of cancer treatment. The autotransplanted tissue has in various centers resulted in the re-establishment of ovarian function leading to the return of fertility and the birth of healthy children [2, 3]. However, the ovarian reserve in the transplanted tissue typically is very low as currently only a limited number of follicles survive the entire procedure including freezing, thawing and transplantation [4]. This diminished reserve is reflected by persistent low levels of AMH [4], limiting the efficacy of controlled ovarian stimulation (COS) with exogenous FSH.

In terms of fertility treatment, the women who have...


Progesterone DHEA Ovarian Tissue Progesterone Level Control Ovarian Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The financial support from the Novo Nordic Foundation, Sophus Carl Emil Friis and wife Olga Doris Friis’ foundation, the Lundbeck Foundation, and the University Hospital of Copenhagen is gratefully acknowledged.

Disclosure summary

The authors have nothing to disclose.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Susanne Strauss
    • 1
  • Tine Greve
    • 1
  • Erik Ernst
    • 2
  • Matthiaos Fraidakis
    • 3
  • Jurgis Gedis Grudzinskas
    • 4
  • Claus Yding Andersen
    • 1
    • 5
  1. 1.Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction – Faculty of Health ScienceUniversity of CopenhagenCopenhagenDenmark
  2. 2.Reproductive Laboratory, Institute of Anatomy, University of Aarhus and Department of Gynaecology and ObstetricsAarhus University HospitalAarhusDenmark
  3. 3.Crete Fertility CentreHeraklionGreece
  4. 4.LondonUK
  5. 5.Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of CopenhagenUniversity of CopenhagenCopenhagenDenmark

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