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Do estrogen receptor alpha polymorphisms have any impact on the outcome in an ART program?

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To investigate two of the most studied estrogen receptor alpha polymorphisms (PvuII and XbaI) in combination, in order to evaluate their impact on an ART program outcome.

Methods

203 normally ovulating women who underwent IVF or ICSI treatment were genotyped for PvuII and XbaI polymorphisms in ESR1 intron 1 using Real-Time PCR. The relationship between the presence of polymorphic alleles and the ovulation induction parameters and outcome was examined.

Results

Women were grouped according to the number of polymorphic alleles they carried in two groups (0–2 versus 3–4 polymorphic alleles). The presence of 3 or more polymorphic alleles was associated with significantly lower E2 levels on the day of hCG administration and a significantly lower rate of good quality embryos.

Conclusion

There is an association between ESR1 polymorphisms and some ART parameters such as the level of E2 on the day of hCG administration and the quality of the embryos. These results underline the importance of ESR1 as a candidate gene for the prediction of ovarian response to IVF/ICSI protocols. Future research work concerning several more genes is necessary for a better evaluation of patients before entering an IVF/ICSI program.

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Authors and Affiliations

  1. Division of Human Reproduction, IVF Unit, 1st Department of Obstetrics and Gynecology, Alexandra Hospital, Athens University Medical School, 80 Vasilissis Sofias Avenue, 11528, Athens, Greece

    Elli Anagnostou, Fotodotis Malamas, Despina Mavrogianni, Vasiliki Dinopoulou, Peter Drakakis, Konstantinos Kallianidis & Dimitris Loutradis

  2. Division of Human Reproduction, IVF Unit, 1st Department of Obstetrics and Gynecology, Alexandra Hospital, Athens University Medical School, 62 Sirinon Str, 17561, P. Faliro, Athens, Greece

    Dimitris Loutradis

Authors
  1. Elli Anagnostou
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  2. Fotodotis Malamas
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  3. Despina Mavrogianni
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  4. Vasiliki Dinopoulou
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  5. Peter Drakakis
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  6. Konstantinos Kallianidis
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  7. Dimitris Loutradis
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Corresponding author

Correspondence to Dimitris Loutradis.

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Capsule

Study of ESR1 PvuII and XbaI gene polymorphisms in women enrolled in IVF/ICSI protocols.

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Anagnostou, E., Malamas, F., Mavrogianni, D. et al. Do estrogen receptor alpha polymorphisms have any impact on the outcome in an ART program?. J Assist Reprod Genet 30, 555–561 (2013). https://doi.org/10.1007/s10815-013-9971-7

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  • DOI: https://doi.org/10.1007/s10815-013-9971-7

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