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Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population

  • Genetics
  • Published:
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Abstract

Objective

Recurrent spontaneous abortion (RSA) is a multifactor and distressing disease. There are still approximately half of the RSA patients with cause not being identified to date. Accumulating studies have confirmed that genetic polymorphisms in glutathione S-transferases (GSTs) were associated with the risk of recurrent spontaneous abortion. In this study, we aimed to investigate the relationship between the polymorphism of GSTA1, which is GSTA1 -69C/T (rs3957357), and the development of recurrent spontaneous abortion.

Methods

A case–control study of 127 cases with RSA and 112 ethnic and age matched women as controls was conducted. And measurement of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was performed to genotype all of samples in order to analyze the association between GSTA1 -69C/T (rs3957357) and the risk of RSA.

Results

We found that the frequencies of genotypes between cases and controls have no significant difference (P = 0.908) and GSTA1 mutant allele GSTA1 −69 T was present at a frequency of 0.122 in case group, while in controls the frequency was 0.125 (P = 0.922).

Conclusion

The polymorphism of GSTA1 (rs3957357) may not be associated with the risk of recurrent spontaneous abortion in Chinese Han population.

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Acknowledgments

This work was supported by the National Basic Research Program of China (2012CB944704), the National Natural Science Foundation of 150 China (30973197), and Anhui Provincial Natural Science Foundation (11010402166).

The authors thank all the women for their cooperation, and thank the clinicians who provided these patients.

Declaration of interest

The authors report no declaration of interest.

Author information

Authors and Affiliations

  1. Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China

    Chen Zong, Huifen Xiang, Dawei Chen & Yunxia Cao

  2. Institute of Reproductive Genetics, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022, China

    Chen Zong, Huifen Xiang, Dawei Chen & Yunxia Cao

  3. Maternal and Child Health Hospital of Xiamen city, Reproductive Medicine Center, 361005, Xiamen city, Fujian Province, China

    Yanwei Sha

  4. Department of Medical Genetics, School of Basic Medical Sciences, Capital Medical University, Beijing, China

    Jing Wang

  5. Center for Genetics, National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 10081, China

    Juan Liu & Binbin Wang

  6. Graduated School, Peking Union Medical College, Beijing, 100080, China

    Binbin Wang

Authors
  1. Chen Zong
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  2. Yanwei Sha
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  3. Huifen Xiang
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  4. Jing Wang
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  5. Dawei Chen
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  6. Juan Liu
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  7. Binbin Wang
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  8. Yunxia Cao
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Corresponding authors

Correspondence to Binbin Wang or Yunxia Cao.

Additional information

Capsule The GSTA1 polymorphism may not be associated with the development of RSA.

Chen Zong and Yanwei Sha contributed equally to the work.

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Zong, C., Sha, Y., Xiang, H. et al. Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population. J Assist Reprod Genet 31, 379–382 (2014). https://doi.org/10.1007/s10815-013-0163-2

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  • DOI: https://doi.org/10.1007/s10815-013-0163-2

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