Journal of Assisted Reproduction and Genetics

, Volume 30, Issue 11, pp 1505–1512 | Cite as

HOXA-11 mediated dysregulation of matrix remodeling during implantation window in women with endometriosis

  • Saikat Kumar Jana
  • Priyanka Banerjee
  • Rashmi Mukherjee
  • Baidyanath Chakravarty
  • Koel ChaudhuryEmail author
Gonadal Physiology and Disease



To investigate the Homeobox genes HOXA-10 and HOXA-11 mediated endometrial molecular defects during implantation window in endometriosis-associated infertility cases.


Endometrial biopsies were obtained during implantation window from 31 infertile women with endometriosis (age < 35 years) and 26 age and BMI-matched infertile women without endometriosis were included in the study for comparison purposes. Endometrial expression of HOXA-10 and HOXA-11 genes, MMP-2, -9, αvβ3 integrin, leukemia inhibitory factor and surface characteristics including average roughness and topology were assessed.


A significantly lower expression of HOXA-10 and HOXA-11 were observed in endometriotic women compared to non-endometriotic controls. Further, a significantly higher endometrial expression of MMP-2 and −9 were observed in women with endometriosis when compared with controls. Interestingly, endometrial surface were observed to be grossly affected in terms of average roughness and topology in women with endometriosis compared to controls.


The findings suggest that aberrant expression of HOXA-10 and −11 genes adversely affects endometrial remodelling and expression of receptivity markers.


HOXA gene Endometrial receptivity Endometrium Atomic force microscopy Endometriosis 



Homeobox genes A


Matrix metalloproteinases


Scanning electron microscope


Atomic force microscope



The authors are grateful to all the volunteers who participated in this study, as well as to Dr. Ratna Chattopadhay and Dr. Pallavi Pasricha from IRM, Kolkata for helping in collection of samples. The first author would like to acknowledge Vishmadeb Pramanik for helping with Real time PCR experiments.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Saikat Kumar Jana
    • 1
  • Priyanka Banerjee
    • 1
  • Rashmi Mukherjee
    • 1
  • Baidyanath Chakravarty
    • 2
  • Koel Chaudhury
    • 1
    • 3
    Email author
  1. 1.School of Medical Science and TechnologyIndian Institute of TechnologyWest BengalIndia
  2. 2.Institute of Reproductive MedicineKolkataIndia
  3. 3.Indian Institute of TechnologyKharagpurIndia

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