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The predictive value of high-magnification sperm morphology examination on ICSI outcomes in the presence of oocyte dysmorphisms

  • Assisted Reproduction Technologies
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Abstract

Purpose

To evaluate the relationship between oocyte dysmorphisms and IMSI outcomes

Methods

Data of IMSI cycles performed in 332 patients were included in this study. Patients were included only if presented more than four and less than 30 oocytes upon oocyte retrieval. Patients who underwent IMSI were matched, concerning female age and sperm parameters, with patients who underwent ICSI in the same period (n = 332). The two groups (ICSI and IMSI) were compared with regard to treatment outcomes. The influence of IMSI on fertilization and embryo quality on D3 and D5, when oocyte dysmorphisms were present was analyzed.

Results

A total of 6444 oocytes were morphologically evaluated and injected. Regardless of the oocyte quality, IMSI performance was a determinant of the increased odds of development to high quality embryo on D3 (OR: 1.98; CI: 1.54–2.56) and D5 (OR: 3.27; CI: 1.61–6.66).

Conclusions

The selection of a morphologically normal spermatozoon under high-magnification is associated with increased embryo quality, regardless of the oocyte morphology. The injection of a spermatozoon, selected under high-magnification, into a morphologically normal oocyte leads to the highest probability of developing high quality embryos.

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Authors and Affiliations

  1. Sapientiae Institute – Educational and Research Center in Assisted Reproduction, Rua Vieira Maciel, 62, São Paulo, SP, Brazil, 04503-040

    Amanda Souza Setti, Daniela Paes Almeida Ferreira Braga, Assumpto Iaconelli Jr. & Edson Borges Jr.

  2. Fertility – Assisted Fertilization Center, Av. Brigadeiro Luis Antonio, 4545, São Paulo, SP, Brazil, 01401-002

    Amanda Souza Setti, Daniela Paes Almeida Ferreira Braga, Rita Cassia Savio Figueira, Assumpto Iaconelli Jr. & Edson Borges Jr.

Authors
  1. Amanda Souza Setti
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  2. Daniela Paes Almeida Ferreira Braga
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  3. Rita Cassia Savio Figueira
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  4. Assumpto Iaconelli Jr.
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  5. Edson Borges Jr.
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Correspondence to Edson Borges Jr..

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Capsule The selection of a morphologically normally spermatozoon under high-magnification is associated with increased embryo quality, regardless of the oocyte morphology.

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Setti, A.S., Braga, D.P.A.F., Figueira, R.C.S. et al. The predictive value of high-magnification sperm morphology examination on ICSI outcomes in the presence of oocyte dysmorphisms. J Assist Reprod Genet 29, 1241–1247 (2012). https://doi.org/10.1007/s10815-012-9868-x

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  • DOI: https://doi.org/10.1007/s10815-012-9868-x

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