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A recent paper implicates cytoplasmic localization as a means for establishing the embryonic and placental lineages in the preimplantation mammalian embryo, including the human.
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Albertini, D.F. The embryos’ geneology-sorting fact from fancy. J Assist Reprod Genet 29, 701–702 (2012). https://doi.org/10.1007/s10815-012-9844-5
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DOI: https://doi.org/10.1007/s10815-012-9844-5