Skip to main content

Advertisement

Log in

Fertility considerations in young women with hematological malignancies

  • Fertility Preservation
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

The need for practice guidelines for fertility preservation in young women with hematological malignancies has been increased. To develop recommendations, publications relevant to fertility preservation and hematological cancers were identified through a PubMed database search and reviewed systematically, focusing on the effects of oncological treatments on fertility as well as on the efficacy, feasibility and risks of existing fertility preservation methods.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Whitehead E, Shalet SM, Blackledge G, Todd I, Crowther D, Beardwell CG. The effect of combination chemotherapy on ovarian function in women treated for Hodgkin’s disease. Cancer. 1983;52(6):988–93.

    Article  PubMed  CAS  Google Scholar 

  2. Longhi A, Pignotti E, Versari M, Asta S, Bacci G. Effect of oral contraceptive on ovarian function in young females undergoing neoadjuvant chemotherapy treatment for osteosarcoma. Oncol Rep. 2003;10(1):151–5.

    PubMed  Google Scholar 

  3. van der Kaaij MA, van Echten-Arends J, Simons AH, Kluin-Nelemans HC. Fertility preservation after chemotherapy for Hodgkin lymphoma. Hematol Oncol. 2010;28(4):168–79.

    Article  PubMed  Google Scholar 

  4. Clowse ME, Behera MA, Anders CK, Copland S, Coffman CJ, Leppert PC, Bastian LA. Ovarian preservation by GnRH agonists during chemotherapy: a meta-analysis. J Womens Health (Larchmt). 2009;18(3):311–9.

    Article  Google Scholar 

  5. Ben-Aharon I, Gafter-Gvili A, Leibovici L, Stemmer SM. Pharmacological interventions for fertility preservation during chemotherapy: a systematic review and meta-analysis. Breast Cancer Res Treat. 2010;122(3):803–11.

    Article  PubMed  Google Scholar 

  6. Kim SS, Lee JR, Jee BC, Suh CS, Kim SH, Ting A, Petroff B. Use of hormonal protection for chemotherapy-induced gonadotoxicity. Clin Obstet Gynecol. 2010;53(4):740–52.

    Article  PubMed  CAS  Google Scholar 

  7. Bedaiwy MA, Abou-Setta AM, Desai N, Hurd W, Starks D, El-Nashar SA, Al-Inany HG, Falcone T. Gonadotropin-releasing hormone analog cotreatment for preservation of ovarian function during gonadotoxic chemotherapy: a systematic review and meta-analysis. Fertil Steril. 2011;95(3):906–14.

    Article  PubMed  CAS  Google Scholar 

  8. Badawy A, Elnashar A, El-Ashry M, Shahat M. Gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage: prospective randomized study. Fertil Steril. 2009;91(3):694–7.

    Article  PubMed  CAS  Google Scholar 

  9. Sverrisdottir A, Nystedt M, Johansson H, Fornander T. Adjuvant goserelin and ovarian preservation in chemotherapy treated patients with early breast cancer: results from a randomized trial. Breast Cancer Res Treat. 2009;117(3):561–7.

    Article  PubMed  CAS  Google Scholar 

  10. del Mastro L, Boni L, Michelotti A, Gamucci T, Olmeo N, Gori S, Giordano M, Garrone O, Pronzato P, Bighin C, Levaggi A, Giraudi S, Cresti N, Magnolfi E, Scotto T, Vecchio C, Venturini M. Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomised trial. J Am Med Assoc. 2011;30(3):269–76.

    Article  Google Scholar 

  11. Behringer K, Wildt L, Mueller H, Mattle V, Ganitis P, van den Hoonaard B, Ott HW, Hofer S, Pluetschow A, Diehl V, Engert A, Borchmann P, German Hodgkin Study Group. No protection of the ovarian follicle pool with the use of GnRH-analogues or oral contraceptives in young women treated with escalated BEACOPP for advanced-stage Hodgkin lymphoma. Final results of a phase II trial from the German Hodgkin Study Group. Ann Oncol. 2010;21(10):2052–60.

    Article  PubMed  CAS  Google Scholar 

  12. Gerber B, von Minckwitz C, Stehle H, Reimer T, Felberbaum R, Maass N, Fischer D, Sommer HL, Conrad B, Ortmann O, Fehm T, Rezai M, Mehta K, Loibl S, German Breast Group Investigators. Effect of luteinizing hormone-releasing hormone agonist on ovarian function after modern adjuvant breast cancer chemotherapy: the GBG 37 ZORO study. J Clinical Oncol. 2011;29(17):2334–41.

    Article  CAS  Google Scholar 

  13. Jadoul P, Anckaert E, Dewandeleer A, Steffens M, Dolmans MM, Vermylen C, Smitz J, Donnez J, Maiter D. Clinical and biologic evaluation of ovarian function in women treated by bone marrow transplantation for various indications during childhood or adolescence. Fertil Steril. 2011;96(1):126–133.e3.

    Article  PubMed  CAS  Google Scholar 

  14. Olive DL. Gonadotropin-releasing hormone agonists for endometriosis. N Engl J Med. 2008;359(11):1136–42.

    Article  PubMed  CAS  Google Scholar 

  15. Nyboe Andersen A, Goossens V, Bhattacharya S, Ferraretti AP, Kupka MS, de Mouzon J, Nygren KG, European IVF-monitoring (EIM) Consortium, for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod. 2009;24(6):1267–87.

    Article  PubMed  CAS  Google Scholar 

  16. Ata B, Chian RC, Tan SL. Cryopreservation of oocytes and embryos for fertility preservation for female cancer patients. Best Pract Res Clin Obstet Gynaecol. 2010;24(1):101–12.

    Article  PubMed  Google Scholar 

  17. Das M, Shehata F, Moria A, Holzer H, Son WY, Tulandi T. Ovarian reserve, response to gonadotropins, and oocyte maturity in women with malignancy. Fertil Steril. 2011;96(1):122–5.

    Article  PubMed  CAS  Google Scholar 

  18. Knopman JM, Noyes N, Talebian S, Krey LC, Grifo JA, Licciardi F. Women with cancer undergoing ART for fertility preservation: a cohort study of their response to exogenous gonadotropins. Fertil Steril. 2009;91(4 Suppl):1476–8.

    Article  PubMed  Google Scholar 

  19. Robertson AD, Missmer SA, Ginsburg ES. Embryo yield after in vitro fertilization in women undergoing embryo banking for fertility preservation before chemotherapy. Fertil Steril. 2011;95(2):588–91.

    Article  PubMed  Google Scholar 

  20. Quintero RB, Helmer A, Huang JQ, Westphal LM. Ovarian stimulation for fertility preservation in patients with cancer. Fertil Steril. 2010;93(3):865–8.

    Article  PubMed  CAS  Google Scholar 

  21. Anderson RA, Wallace WH. Fertility preservation in girls and young women. Clin Endocrinol (Oxf). 2011;75(4):409–19. doi:10.1111/j.1365-2265.2011.04100.x.

    Article  Google Scholar 

  22. Leader A, Lishner M, Michaeli J, Revel A. Fertility considerations and preservation in haemato-oncology patients undergoing treatment. Br J Haematol. 2011;153(3):291–308.

    Article  PubMed  Google Scholar 

  23. von Wolff M, Montag M, Dittrich R, Denschlag D, Nawroth F, Lawrenz B. Fertility preservation in women-a practical guide to preservation techniques and therapeutic strategies in breast cancer, Hodgkin’s lymphoma and borderline ovarian tumours by the fertility preservation network FertiPROTEKT. Arch Gynecol Obstet. 2011;284(2):427–35.

    Article  Google Scholar 

  24. von Wolff M, Thaler CJ, Frambach T, Zeeb C, Lawrenz B, Popovici RM, Strowitzki T. Ovarian stimulation to cryopreserve fertilized oocytes in cancer patients can be started in the luteal phase. Fertil Steril. 2009;92(4):1360–5.

    Article  Google Scholar 

  25. Dolmans MM, Demylle D, Martinez-Madrid B, Donnez J. Efficacy of in vitro fertilization after chemotherapy. Fertil Steril. 2005;83(4):897–901.

    Article  PubMed  Google Scholar 

  26. Meirow D, Schiff E. Appraisal of chemotherapy effects on reproductive outcome according to animal studies and clinical data. J Natl Cancer Inst Monogr. 2005;34:21–5.

    Article  PubMed  CAS  Google Scholar 

  27. Oktay K, Hourvitz A, Sahin G, Oktem O, Safro B, Cil A, Bang H. Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy. J Clin Endocrinol Metab. 2006;91(10):3885–90.

    Article  PubMed  CAS  Google Scholar 

  28. Kol S, Solt I. GnRH agonist for triggering final oocyte maturation in patients at risk of ovarian hyperstimulation syndrome: still a controversy? J Assist Reprod Genet. 2008;25(2–3):63–6.

    Article  PubMed  CAS  Google Scholar 

  29. Kolibianakis EM, Venetis CA, Tarlatzis BC. Cryopreservation of human embryos by vitrification or slow freezing: which one is better? Curr Opin Obstet Gynecol. 2009;21(3):270–4.

    Article  PubMed  Google Scholar 

  30. Moria A, Das M, Shehata F, Holzer H, Son WY, Tulandi T. Ovarian reserve and oocyte maturity in women with malignancy undergoing in vitro maturation treatment. Fertil Steril. 2011;95(5):1621–3.

    Article  PubMed  Google Scholar 

  31. Maman E, Meirow D, Brengauz M, Raanani H, Dor J, Hourvitz A. Luteal phase oocyte retrieval and in vitro maturation is an optional procedure for urgent fertility preservation. Fertil Steril. 2011;95(1):64–7.

    Article  PubMed  Google Scholar 

  32. Huang JY, Tulandi T, Holzer H, Tan SL, Chian RC. Combining ovarian tissue cryobanking with retrieval of immature oocytes followed by in vitro maturation and vitrification: an additional strategy of fertility preservation. Fertil Steril. 2008;89(3):567–72.

    Article  PubMed  Google Scholar 

  33. Revel A, Revel-Vilk S, Aizenman E, Porat-Katz A, Safran A, Ben-Meir A, Weintraub M, Shapira M, Achache H, Laufer N. At what age can human oocytes be obtained? Fertil Steril. 2009;92(2):458–63.

    Article  PubMed  Google Scholar 

  34. Chian RC, Buckett WM, Tan SL. In-vitro maturation of human oocytes. Reprod Biomed Online. 2004;8(2):148–66.

    Article  PubMed  Google Scholar 

  35. Chen C. Pregnancy after human oocyte cryopreservation. Lancet. 1986;1:884–6.

    Article  PubMed  CAS  Google Scholar 

  36. Oktay K, Cil AP, Bang H. Efficiency of oocyte cryopreservation: a meta-analysis. Fertil Steril. 2006;86(1):70–80.

    Article  PubMed  Google Scholar 

  37. Cobo A, Domingo J, Pérez S, Crespo J, Remohí J, Pellicer A. Vitrification: an effective new approach to oocyte banking and preserving fertility in cancer patients. Clin Transl Oncol. 2008;10(5):268–73.

    Article  PubMed  CAS  Google Scholar 

  38. Cobo A, Meseguer M, Remohí J, Pellicer A. Use of cryo-banked oocytes in an ovum donation programme: a prospective, randomized, controlled, clinical trial. Hum Reprod. 2010;25(9):2239–46.

    Article  PubMed  Google Scholar 

  39. Yang D, Brown SE, Nguyen K, Reddy V, Brubaker C, Winslow KL. Live birth after the transfer of human embryos developed from cryopreserved oocytes harvested before cancer treatment. Fertil Steril. 2007;87(6):1469.

    Article  PubMed  Google Scholar 

  40. Chian RC, Huang JY, Tan SL, Lucena E, Saa A, Rojas A, Ruvalcaba Castellón LA, García Amador MI, Montoya Sarmiento JE. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reprod Biomed Online. 2008;16(5):608–10.

    Article  PubMed  Google Scholar 

  41. Noyes N, Porcu E, Borini A. Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod Biomed Online. 2009;18(6):769–76.

    Article  PubMed  CAS  Google Scholar 

  42. Jadoul P, Dolmans MM, Donnez J. Fertility preservation in girls during childhood: is it feasible, efficient and safe and to whom should it be proposed? Hum Reprod Update. 2010;16(6):617–30.

    Article  PubMed  Google Scholar 

  43. Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, Martinez-Madrid B, van Langendonckt A. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364(9443):1405–10.

    Article  PubMed  CAS  Google Scholar 

  44. Donnez J, Silber S, Andersen CY, Demeestere I, Piver P, Meirow D, Pellicer A, Dolmans MM. Children born after autotransplantation of cryopreserved ovarian tissue. A review of 13 live births. Ann Med. 2011;43(6):437–50. doi:10.3109/07853890.2010.546807.

    Article  PubMed  Google Scholar 

  45. Andersen CY, Rosendahl M, Byskov AG, Loft A, Ottosen C, Dueholm M, Schmidt KL, Andersen AN, Ernst E. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod. 2008;23(10):2266–72.

    Article  PubMed  Google Scholar 

  46. Dolmans MM, Donnez J, Camboni A, Demylle D, Amorim C, Van Langendonckt A, Pirard C. IVF outcome in patients with orthotopically transplanted ovarian tissue. Hum Reprod. 2009;24(11):2778–87.

    Article  PubMed  Google Scholar 

  47. Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, Schiff E, Dor J. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353(3):318–21.

    Article  PubMed  CAS  Google Scholar 

  48. Hovatta O. Cryopreservation and culture of human ovarian cortical tissue containing early follicles. Eur J Obstet Gynecol Reprod Biol. 2004;113 Suppl 1:S50–4.

    Article  PubMed  Google Scholar 

  49. Picton HM, Harris SE, Muruvi W, Chambers EL. The in vitro growth and maturation of follicles. Reproduction. 2008;136(6):703–15.

    Article  PubMed  CAS  Google Scholar 

  50. Dolmans MM, Martinez-Madrid B, Gadisseux E, Guiot Y, Yuan WY, Torre A, Camboni A, Van Langendonckt A, Donnez J. Short-term transplantation of isolated human ovarian follicles and cortical tissue into nude mice. Reproduction. 2007;134(2):253–62.

    Article  PubMed  CAS  Google Scholar 

  51. Telfer EE, McLaughlin M, Ding C, Thong KJ. A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin. Hum Reprod. 2008;23(5):1151–8.

    Article  PubMed  CAS  Google Scholar 

  52. Xu M, Barrett SL, West-Farrell E, Kondapalli LA, Kiesewetter SE, Shea LD, Woodruff TK. In vitro grown human ovarian follicles from cancer patients support oocyte growth. Hum Reprod. 2009;24(10):2531–40.

    Article  PubMed  CAS  Google Scholar 

  53. Amorim CA, Van Langendonckt A, David A, Dolmans MM, Donnez J. Survival of human pre-antral follicles after cryopreservation of ovarian tissue, follicular isolation and in vitro culture in a calcium alginate matrix. Hum Reprod. 2009;24(1):92–9.

    Article  PubMed  CAS  Google Scholar 

  54. Desai N, Alex A, AbdelHafez F, Calabro A, Goldfarb J, Fleischman A, Falcone T. Three-dimensional in vitro follicle growth: overview of culture models, biomaterials, design parameters and future directions. Reprod Biol Endocrinol. 2010;8:119.

    Article  PubMed  Google Scholar 

  55. Thibaud E, Ramirez M, Brauner R, Flamant F, Zucker JM, Fekete C, Rappaport R. Preservation of ovarian function by ovarian transposition performed before pelvic irradiation during childhood. J Pediatr. 1992;121:880–4.

    Article  PubMed  CAS  Google Scholar 

  56. Morice P, Juncker L, Rey A, El-Hassan J, Haie-Meder C, Castaigne D. Ovarian transposition for patients with cervical carcinoma treated by radiosurgical combination. Fertil Steril. 2000;74:743–8.

    Article  PubMed  CAS  Google Scholar 

  57. Aubard Y, Piver P, Pech JC, Galinat S, Teissier MP. Ovarian tissue cryopreservation and gynecologic oncology: a review. Eur J Obstet Gynecol Reprod Biol. 2001;97:5–14.

    Article  PubMed  CAS  Google Scholar 

  58. Scott SM, Schlaff W. Laparoscopic medial oophoropexy prior to radiation therapy in an adolescent with Hodgkin’s disease. J Pediatr Adol Gynecol. 2005;18:355–7.

    Article  Google Scholar 

  59. Sonmezer M, Oktay K. Fertility preservation in female patients. Hum Reprod Update. 2004;10:251–66.

    Article  PubMed  Google Scholar 

  60. The Leukemia and Lymphoma Society, Facts 2010–2011

  61. Kiserud CE, Fosså A, Holte H, Fosså SD. Post-treatment parenthood in Hodgkin’s lymphoma survivors. Br J Cancer. 2007;96(9):1442–9.

    PubMed  CAS  Google Scholar 

  62. Hodgson DC, Pintilie M, Gitterman L, Dewitt B, Buckley CA, Ahmed S, Smith K, Schwartz A, Tsang RW, Crump M, Wells W, Sun A, Gospodarowicz MK. Fertility among female hodgkin lymphoma survivors attempting pregnancy following ABVD chemotherapy. Hematol Oncol. 2007;25(1):11–5.

    Article  PubMed  Google Scholar 

  63. De Bruin ML, Huisbrink J, Hauptmann M, Kuenen MA, Ouwens GM, van’t Veer MB, Aleman BM, van Leeuwen FE. Treatment-related risk factors for premature menopause following Hodgkin lymphoma. Blood. 2008;111(1):101–8.

    Article  PubMed  Google Scholar 

  64. Brusamolino E, Bacigalupo A, Barosi G, Biti G, Gobbi PG, Levis A, Marchetti M, Santoro A, Zinzani PL, Tura S. Classical Hodgkin’s lymphoma in adults: guidelines of the Italian Society of Hematology, the Italian Society of Experimental Hematology, and the Italian Group for Bone Marrow Transplantation on initial work-up, management, and follow-up. Haematologica. 2009;94(4):550–65.

    Article  PubMed  Google Scholar 

  65. Engert A, Eichenauer DA, Dreyling M, ESMO Guidelines Working Group. Hodgkin’s lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2010;21 Suppl 5:v168–71.

    Article  PubMed  Google Scholar 

  66. Meirow D, Ben Yehuda D, Prus D, Poliack A, Schenker JG, Rachmilewitz EA, Lewin A. Ovarian tissue banking in patients with Hodgkin’s disease: is it safe? Fertil Steril. 1998;69(6):996–8.

    Article  PubMed  CAS  Google Scholar 

  67. Kim SS, Radford J, Harris M, Varley J, Rutherford AJ, Lieberman B, Shalet S, Gosden R. Ovarian tissue harvested from lymphoma patients to preserve fertility may be safe for autotransplantation. Hum Reprod. 2001;16(10):2056–60.

    Article  PubMed  CAS  Google Scholar 

  68. Seshadri T, Gook D, Lade S, Spencer A, Grigg A, Tiedemann K, McKendrick J, Mitchell P, Stern C, Seymour JF. Lack of evidence of disease contamination in ovarian tissue harvested for cryopreservation from patients with Hodgkin lymphoma and analysis of factors predictive of oocyte yield. Br J Cancer. 2006;94(7):1007–10.

    Article  PubMed  CAS  Google Scholar 

  69. Bittinger SE, Nazaretian SP, Gook DA, Parmar C, Harrup RA, Stern CJ. Detection of Hodgkin lymphoma within ovarian tissue. Fertil Steril. 2011;95(2):803.e3–6.

    Article  Google Scholar 

  70. Lucia SP, Mills H, Lowenhaupt E, Hunt ML. Visceral involvement in primary neoplastic diseases of the reticulo-endothelial system. Cancer. 1952;5(6):1193–200.

    Article  PubMed  CAS  Google Scholar 

  71. Chorlton I, Norris HJ, King FM. Malignant reticuloendothelial disease involving the ovary as a primary manifestation: a series of 19 lymphomas and 1 granulocytic sarcoma. Cancer. 1974;34(2):397–407.

    Article  PubMed  CAS  Google Scholar 

  72. von der Weid NX. Adult life after surviving lymphoma in childhood. Support Care Cancer. 2008;16(4):339–45.

    Article  PubMed  Google Scholar 

  73. Müller U, Stahel RA. Gonadal function after MACOP-B or VACOP-B with or without dose intensification and ABMT in young patients with aggressive non-Hodgkin’s lymphoma. Ann Oncol. 1993;4(5):399–402.

    PubMed  Google Scholar 

  74. Elis A, Tevet A, Yerushalmi R, Blickstein D, Bairy O, Dann EJ, Blumenfeld Z, Abraham A, Manor Y, Shpilberg O, Lishner M. Fertility status among women treated for aggressive non-Hodgkin’s lymphoma. Leuk Lymphoma. 2006;47(4):623–7.

    Article  PubMed  Google Scholar 

  75. Seshadri T, Hourigan MJ, Wolf M, Mollee PN, Seymour JF. The effect of the Hyper-CVAD chemotherapy regimen on fertility and ovarian function. Leuk Res. 2006;30(4):483–5.

    Article  PubMed  CAS  Google Scholar 

  76. Shaw JM, Bowles J, Koopman P, Wood EC, Trounson AO. Fresh and cryopreserved ovarian tissue samples from donors with lymphoma transmit the cancer to graft recipients. Hum Reprod. 1996;11(8):1668–73.

    Article  PubMed  CAS  Google Scholar 

  77. Watson M, Wheatley K, Harrison GA, Zittoun R, Gray RG, Goldstone AH, Burnett AK. Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. Cancer. 1999;86(7):1231–9.

    Article  PubMed  CAS  Google Scholar 

  78. Liesner RJ, Leiper AD, Hann IM, Chessells JM. Late effects of intensive treatment for acute myeloid leukemia and myelodysplasia in childhood. J ClinOncol. 1994;12(5):916–24.

    CAS  Google Scholar 

  79. Byrne J, Fears TR, Mills JL, Zeltzer LK, Sklar C, Nicholson HS, Haupt R, Reaman GH, Meadows AT, Robison LL. Fertility in women treated with cranial radiotherapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2004;42(7):589–97.

    Article  PubMed  Google Scholar 

  80. Brydøy M, Fosså SD, Dahl O, Bjøro T. Gonadal dysfunction and fertility problems in cancer survivors. Acta Oncol. 2007;46(4):480–9.

    Article  PubMed  Google Scholar 

  81. Dolmans MM, Marinescu C, Saussoy P, Van Langendonckt A, Amorim C, Donnez J. Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe. Blood. 2010;116(16):2908–14.

    Article  PubMed  CAS  Google Scholar 

  82. Meirow D, Hardan I, Dor J, Fridman E, Elizur S, Ra’anani H, Slyusarevsky E, Amariglio N, Schiff E, Rechavi G, Nagler A, Ben Yehuda D. Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. Hum Reprod. 2008;23(5):1007–13.

    Article  PubMed  Google Scholar 

  83. Familiari G, Caggiati A, Nottola SA, Ermini M, Di Benedetto MR, Motta PM. Ultrastructure of human ovarian primordial follicles after combination chemotherapy for Hodgkin’s disease. Hum Reprod. 1993;8(12):2080–7.

    PubMed  CAS  Google Scholar 

  84. Leung W, Hudson MM, Strickland DK, Phipps S, Srivastava DK, Ribeiro RC, Rubnitz JE, Sandlund JT, Kun LE, Bowman LC, Razzouk BI, Mathew P, Shearer P, Evans WE, Pui CH. Late effects of treatment in survivors of childhood acute myeloid leukemia. J Clin Oncol. 2000;18(18):3273–9.

    PubMed  CAS  Google Scholar 

  85. Conchon M, Sanabani SS, Bendit I, Santos FM, Serpa M, Dorliac-Llacer PE. Two successful pregnancies in a woman with chronic myeloid leukemia exposed to nilotinib during the first trimester of her second pregnancy: case study. J Hematol Oncol. 2009;2:42.

    Article  PubMed  Google Scholar 

  86. Cole S, Kantarjian H, Ault P, Cortés JE. Successful completion of pregnancy in a patient with chronic myeloid leukemia without active intervention: a case report and review of the literature. Clin Lymphoma Myeloma. 2009;9(4):324–7.

    Article  PubMed  CAS  Google Scholar 

  87. Kyono K, Doshida M, Toya M, Sato Y, Akahira J, Sasano H. Potential indications for ovarian autotransplantation based on the analysis of 5,571 autopsy findings of females under the age of 40 in Japan. Fertil Steril. 2010;93(7):2429–30.

    Article  PubMed  Google Scholar 

  88. Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P, Van Lint MT, Powles R, Jackson G, Hinterberger-Fischer M, Kolb HJ, Apperley JF. Late Effects Working Party of the European Group for Blood and Marrow Transplantation. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet. 2001;358(9278):271–6.

    Article  PubMed  CAS  Google Scholar 

  89. Spinelli S, Chiodi S, Bacigalupo A, Brasca A, Menada MV, Petti AR, Ravera G, Gualandi F, VanLint MT, Sessarego M, et al. Ovarian recovery after total body irradiation and allogeneic bone marrow transplantation: long-term follow up of 79 females. Bone Marrow Transplant. 1994;14(3):373–80.

    Article  PubMed  CAS  Google Scholar 

  90. Sanders JE, Hawley J, Levy W, Gooley T, Buckner CD, Deeg HJ, Doney K, Storb R, Sullivan K, Witherspoon R, Appelbaum FR. Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood. 1996;87(7):3045–52.

    PubMed  CAS  Google Scholar 

  91. Sanders JE, Pritchard S, Mahoney P, Amos D, Buckner CD, Witherspoon RP, Deeg HJ, Doney KC, Sullivan KM, Appelbaum FR, et al. Growth and development following marrow transplantation for leukemia. Blood. 1986;68(5):1129–35.

    PubMed  CAS  Google Scholar 

  92. Leiper AD, Stanhope R, Lau T, Grant DB, Blacklock H, Chessells JM, Plowman PN. The effect of total body irradiation and bone marrow transplantation during childhood and adolescence on growth and endocrine function. Br J Haematol. 1987;67(4):419–26.

    Article  PubMed  CAS  Google Scholar 

  93. Tauchmanovà L, De Rosa G, Serio B, Fazioli F, Mainolfi C, Lombardi G, Colao A, Salvatore M, Rotoli B, Selleri C. Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: a single center experience and a review. Cancer. 2003;97(10):2453–61.

    Article  PubMed  Google Scholar 

  94. Carter A, Robison LL, Francisco L, Smith D, Grant M, Baker KS, Gurney JG, McGlave PB, Weisdorf DJ, Forman SJ, Bhatia S. Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the Bone Marrow Transplant Survivor Study. Bone Marrow Transplant. 2006;37(11):1023–9.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Consortia

Corresponding author

Correspondence to S. Samuel Kim.

Additional information

Capsule

ISFP Practice Committee: S. Samuel Kim, Jacques Donnez, Pedro Barri, Antonio Pellicer, Pasquale Patrizio, Zev Rosenwaks, Peter Nagy, Tommaso Falcone, Claus Andersen, Outi Hovatta, Hamish Wallace, Dror Meirow, Debra Gook, Seok H Kim, Chii-Ruey Tzeng, Shuetu Suzuki, Bunpei Ishizuka, Marie-Madeleine Dolmans

Statements and opinions expressed in articles and communications herein are those of the author(s) and not necessarily those of the editor, publisher, or the American Society for Reproductive Medicine, or any organizations endorsing this journal. Neither the editor, publisher, nor organizations endorsing this journal, guarantee, warrant, or endorse any product or service advertised in this journal, nor do they guarantee any claim made by the manufacturer of such product or service. Except as noted, authors have reported no competing interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jadoul, P., Kim, S.S. & on behalf of ISFP Practice Committee. Fertility considerations in young women with hematological malignancies. J Assist Reprod Genet 29, 479–487 (2012). https://doi.org/10.1007/s10815-012-9792-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10815-012-9792-0

Keywords

Navigation