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Journal of Assisted Reproduction and Genetics

, Volume 29, Issue 8, pp 779–781 | Cite as

Embryo transfer following in vitro maturation and cryopreservation of oocytes recovered from antral follicles during conservative surgery for ovarian cancer

  • Rubens Fadini
  • Mariabeatrice Dal Canto
  • Mario Mignini Renzini
  • Rodolfo Milani
  • Robert Fruscio
  • Maria Grazia Cantù
  • Fausta Brambillasca
  • Giovanni Coticchio
Fertility Preservation

Introduction

Therapeutic advances have significantly improved the prognosis of cancer patients [1]. This has generated new expectations especially for women of adolescent and reproductive age for whom an increased hope of recovery from disease implies a prospect of parenthood [2]. Unfortunately, radio- and chemotherapies have major effects on ovarian function, often leading to premature ovarian failure. Over the last several years, different strategies have been developed to preserve female germ cells and, with them, reproductive function. Before a cancer treatment is started, parts of ovarian cortex can be explanted, cryopreserved and re-implanted orthotopically after clinical remission. With this approach, ovarian and reproductive function can be restored, at least transiently, as demonstrated by the birth of naturally conceived children [3]. Alternatively, following controlled ovarian stimulation, mature oocytes can be retrieved, cryopreserved and used at later stages to achieve a...

Keywords

Cumulus Cell Antral Follicle Fertility Preservation Germinal Vesicle Premature Ovarian Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Rubens Fadini
    • 1
  • Mariabeatrice Dal Canto
    • 1
  • Mario Mignini Renzini
    • 1
  • Rodolfo Milani
    • 2
  • Robert Fruscio
    • 2
  • Maria Grazia Cantù
    • 2
  • Fausta Brambillasca
    • 1
  • Giovanni Coticchio
    • 1
  1. 1.Biogenesi, Reproductive Medicine Centre, Istituti Clinici ZucchiMonzaItaly
  2. 2.Department of Surgical Sciences, Section of Gynaecology, San Gerardo HospitalUniversity of Milano-BicoccaMonzaItaly

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