Embryo transfer following in vitro maturation and cryopreservation of oocytes recovered from antral follicles during conservative surgery for ovarian cancer
Therapeutic advances have significantly improved the prognosis of cancer patients . This has generated new expectations especially for women of adolescent and reproductive age for whom an increased hope of recovery from disease implies a prospect of parenthood . Unfortunately, radio- and chemotherapies have major effects on ovarian function, often leading to premature ovarian failure. Over the last several years, different strategies have been developed to preserve female germ cells and, with them, reproductive function. Before a cancer treatment is started, parts of ovarian cortex can be explanted, cryopreserved and re-implanted orthotopically after clinical remission. With this approach, ovarian and reproductive function can be restored, at least transiently, as demonstrated by the birth of naturally conceived children . Alternatively, following controlled ovarian stimulation, mature oocytes can be retrieved, cryopreserved and used at later stages to achieve a...
KeywordsCumulus Cell Antral Follicle Fertility Preservation Germinal Vesicle Premature Ovarian Failure
- 1.Mertens AC, Yasui Y, Neglia JP, Potter JD, Nesbit ME, Ruccione K, et al. Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol: Official Journal of the American Society of Clinical Oncology. 2001;19:3163–72.Google Scholar
- 5.Huang JYJ, Chian RC, Gilbert L, Fleiszer D, Holzer H, Dermitas E, et al. Retrieval of immature oocytes from unstimulated ovaries followed by in vitro maturation and vitrification: a novel strategy of fertility preservation for breast cancer patients. AJS. 2010;200:177–83.Google Scholar
- 6.Beahrs O, Henson D, Hutter R, Myers M, editors. AJCC Cancer Staging Manual. 3rd edn. American Joint Committee on Cancer. 3rd ed. Philadelphia; 1998.Google Scholar