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Sperm nucleus decondensation, hyaluronic acid (HA) binding and oocyte activation capacity: different markers of sperm immaturity? Case reports

  • Gamete Biology
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Authors and Affiliations

  1. UNILABS, Clinique de la Muette, 55 Rue St Didier, 75116, Paris, France

    Am Junca, Beatriz Gonzalez Marti, Didier De la fontaine, Moncef Benkhalifa & Yves Ménézo

  2. Stazione Zoologica, Villa comunale 1, 80121, Naples, Italy

    Elisabetta Tosti

  3. Procrelys, Maison médicale Ambroise Paré, 28 avenue Rockefeller, 69008, Lyon, France

    Marc Cohen & Yves Ménézo

  4. UNILABS Clinique du Cotentin, 50120 Equeurdreville et Laboratoire d’Eylau, 55 rue St Didier, Paris, 75116, France

    Yves Ménézo

Authors
  1. Am Junca
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  2. Beatriz Gonzalez Marti
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  3. Elisabetta Tosti
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  4. Marc Cohen
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  5. Didier De la fontaine
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  6. Moncef Benkhalifa
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  7. Yves Ménézo
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Corresponding author

Correspondence to Yves Ménézo.

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Capsule

Based on several observations in infertile couples, we have found that immaturity based on HA binding and nucleus decondensation have not exactly the same feature. However both anomalies can be cured by manipulation of the one carbon metabolism, improving homocysteine recycling i.e. vitamins of the group B and Zinc. Our observations confirm that in human sperm, fertility potential is highly dependent of methylation.

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Junca, A., Gonzalez Marti, B., Tosti, E. et al. Sperm nucleus decondensation, hyaluronic acid (HA) binding and oocyte activation capacity: different markers of sperm immaturity? Case reports. J Assist Reprod Genet 29, 353–355 (2012). https://doi.org/10.1007/s10815-012-9710-5

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  • DOI: https://doi.org/10.1007/s10815-012-9710-5

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