Combined strategy for fertility preservation in an oncologic patient: vitrification of in vitro matured oocytes and ovarian tissue freezing
Breast cancer is the most common malignancy in women and nearly 7% of cases are diagnosed before age 40 . Diagnosis at early ages is associated with a worse prognosis and therefore, these cases are usually managed with adjuvant chemotherapy and/or hormonal therapy. These treatments are effective in reducing recurrence rates and improving survival rates; however, they have a negative impact on ovarian function and fertility . Fertility preservation in these cases may be of interest also due to the current trend towards delaying motherhood, which leads to a situation where many women may have not fulfilled their motherhood desire at the time of breast cancer diagnosis.
There are several strategies to preserve fertility. Choosing one or the other will depend on patient’s age, tumour biology and, above all, time availability until the start of gonadotoxic treatment.
We report a case of a 28-year-old patient without relevant past medical history. Menarche...
KeywordsOvarian Tissue Ovarian Stimulation Invasive Lobular Carcinoma Antral Follicle Fertility Preservation
This work was performed under the auspices of “Catedra d’Investigació en Obstetricia, Ginecología i Reproducció” of Department of Obstetrics and Gynaecology, USP-Institut Universitari Dexeus, Universitat Autònoma de Barcelona.
- 12.Rosendahl M, Timmermans Wielenga V, Nedergaard L, Kristensen SG, Ernst E, Rasmussen PE, et al. Cryopreservation of ovarian tissue for fertility preservation: no evidence of malignant cell contamination in ovarian tissue from patients with breast cancer. Fertil Steril. 2011;95:2158–61.PubMedCrossRefGoogle Scholar