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Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome

  • Gonadal Physiology and Disease
  • Published:
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Abstract

Purpose

This study examined the possible association of G241R and K469E single nucleotide polymorphisms (SNPs) of ICAM-1 gene with the occurrence and clinical/biochemical characteristics of polycystic ovary syndrome (PCOS).

Methods

G241R and K469E SNPs in DNA from peripheral blood leukocytes of 169 PCOS and 259 healthy control women were investigated by real-time PCR combined with melting curve analysis using fluorescence-labeled hybridization probes.

Results

We did not find significant differences in the distributions of G241R and K469E polymorphisms, nor in the haplotype frequencies between PCOS and control women. None of the studied polymorphisms were found to affect insulin resistance indices significantly.

Conclusions

These preliminary results suggest that the 241 and 469 SNPs of ICAM-1 gene may not be risk factors for PCOS. Further studies with a larger cohort, analyzing other ICAM-1 polymorphisms are necessary to support our observations before any statement can be made about the relationship between PCOS and ICAM-1 polymorphisms.

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Acknowledgement

This study was supported by the Research Fund of the University of Istanbul (Project no. 2256).

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Authors and Affiliations

  1. Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, 34093, Istanbul, Turkey

    Pervin Vural, Müge Kanmaz-Özer, Semra Doğru-Abbasoğlu & Müjdat Uysal

  2. Maternal and Fetal Unit, Department of Obstetrics and Gynecology, Istanbul Bakirkoy Women and Children Hospital, Istanbul, Turkey

    Ali Gedikbaşı

  3. Department of Internal Medicine, Division of Endocrinology, ÅžiÅŸli Etfal Research and Training Hospital, ÅžiÅŸli, Istanbul, Turkey

    Esra Çil & Berrin Karadağ

Authors
  1. Pervin Vural
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  2. Müge Kanmaz-Özer
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  4. Ali Gedikbaşı
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Correspondence to Pervin Vural.

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Capsule

There are no significant differences in the distributions of ICAM-1 G241R and K469E polymorphisms, and in the haplotype frequencies between PCOS and control women.

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Vural, P., Kanmaz-Özer, M., Doğru-Abbasoğlu, S. et al. Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome. J Assist Reprod Genet 28, 869–875 (2011). https://doi.org/10.1007/s10815-011-9607-8

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  • DOI: https://doi.org/10.1007/s10815-011-9607-8

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