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Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

  • ASSISTED REPRODUCTION TECHNOLOGIES
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Abstract

Purpose

We aimed to analyse the in vitro fertilization-embryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin.

Methods

A total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n = 30) had underwent the IVF-ET with melatonin administration and the control group (group B, n = 30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups.

Results

Sleeping status change was not significant (p > 0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p = 0.0001; p = 0.0001; p < 0.05 respectively.

Conclusion

IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.

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Conflicts of interest

We confirm that the submitting authors have no conflicts of interest to declare.

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We declare that that this article has not been published elsewhere; it is not being considered for publication elsewhere; and it has been submitted with the full knowledge and approval of the institution or organization given as the affiliation of the authors.

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Authors and Affiliations

  1. IVF Department, Zekai Tahir Burak Women Education and Research Hospital, Devlet Mah. Subay Loj.Hızırreis Apt. No:19/11 Yenisehir, Ankara, Turkey

    Ozlem Gun Eryilmaz, Aysun Devran, Esma Sarikaya, Leyla Mollamahmutoğlu & Nedim Cicek

  2. Department of Public Health, Faculty of Medicine, Gazi University, Ankara, Turkey

    Fatma Nur Aksakal

Authors
  1. Ozlem Gun Eryilmaz
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  2. Aysun Devran
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  3. Esma Sarikaya
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  4. Fatma Nur Aksakal
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  5. Leyla Mollamahmutoğlu
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  6. Nedim Cicek
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Correspondence to Ozlem Gun Eryilmaz.

Additional information

Capsule Melatonin may be helpful in fixing the quality problems of the ocyte in IVF patients who suffer from sleep disturbances.

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Eryilmaz, O.G., Devran, A., Sarikaya, E. et al. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. J Assist Reprod Genet 28, 815–820 (2011). https://doi.org/10.1007/s10815-011-9604-y

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  • DOI: https://doi.org/10.1007/s10815-011-9604-y

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