Abstract
Purpose
To report the outcome of intracytoplasmic sperm injection (ICSI) cycles of an oligozoospermic man with reciprocal translocation.
Methods
Two ICSI cycles were given to a 29-year-old man with severe oligozoospermia and reciprocal translocation t(18;21)(p11;q21) and his wife. In the first cycle, no sperm were found in his semen and all 15 oocytes retrieved were donated to another infertile couple suffering from oligozoospermia and premature ovarian failure. In the second cycle, sperm from the husband’s ejaculate were used to fertilize 13 retrieved oocytes.
Results
Eleven embryos were acquired and a healthy girl was born in the oocyte-donated ICSI cycle. In the second cycle, 6 embryos were acquired and only biochemical pregnancy was achieved after three times of embryo transfer.
Conclusions
By the unusual oocyte-donating ICSI procedures, impact of the new reported reciprocal translocation t (18; 21) (p11; q21) on male fertility and embryo development was suggested.
References
Shah K, Sivapalan G, Gibbons N, Tempest H, Griffin DK. The genetic basis of infertility. Reproduction. 2003;126(1):13–25.
Poongothai J, Gopenath TS, Manonayaki S. Genetics of human male infertility. Singapore Med J. 2009;50(4):336–47.
Wiland E, Wojda A, Kamieniczna M, Szczygiel M, Kurpisz M. Infertility status of male individuals with abnormal spermiogram evaluated by cytogenetic analysis and in vitro sperm penetration assay. Med Sci Monit. 2002;8(5):CR394–400.
Pernice F, Mazza G, Puglisi D, Luppino MG, Frisina N. Nonrobertsonian translocation t (6; 11) is associated with infertility in an oligoazoospermic male. Fertil Steril. 2002;78(1):192–4.
Meza-Espinoza JP, Anguiano LO, Rivera H. Chromosomal abnormalities in couples with reproductive disorders. Gynecol Obstet Invest. 2008;66(4):237–40.
Van Assche E, Bonduelle M, Tournaye H, Joris H, Verheyen G, Devroey P, et al. Cytogenetics of infertile men. Hum Reprod. 1996;11 Suppl 4:1–24. discussion 25–26.
World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. Cambridge: Cambridge University Press; 1999.
Mikelsaar R, Pauklin M, Lissitsina J, Punab M. Reciprocal translocation t (7; 16) (q21.2; p13.3) in an infertile man. Fertil Steril. 2006;86(3):719.e9–11.
Aydos SE, Tukun A. Infertility in a man with oligoathenoteratozoospermia associated with nonrobersonian translocation t (9; 15) (p10; q10). Fertil Steril. 2006;86(4):1001.e7–e9.
Rosenmann A, Wahrman J, Richler C, Voss R, Persitz A, Goldman B. Meiotic association between the XY chromosomes and unpaired autosomal elements as a cause of human male sterility. Cytogenet Cell Genet. 1985;39(1):19–29.
Ogilvie CM, Braude P, Scriven PN. Successful pregnancy outcomes after preimplantation genetic diagnosis (PGD) for carriers of chromosome translocations. Hum Fertil (Camb). 2001;4(3):168–71.
Ozawa N, Maruyama T, Nagashima T, Ono M, Arase T, Ishimoto H, et al. Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss. Fertil Steril. 2008;90(4):1301–4.
Leclercq S, Auger J, Dupont C, Le Tessier D, Lebbar A, Baverel F, et al. Sperm FISH analysis in two healthy infertile brothers with t(15;18) unbalanced translocation: Implications for genetic counselling and reproductive management. Eur J Med Genet. 2010;53(3):127–32.
Fischer J, Colls P, Escudero T, Munne S. Preimplantation genetic diagnosis (PGD) improves pregnancy outcome for translocation carriers with a history of recurrent losses. Fertil Steril. 2010;94(1):283–9.
Wiland E, Hobel CJ, Hill D, Kurpisz M. Successful pregnancy after preimplantation genetic diagnosis for carrier of t(2;7)(p11.2;q22) with high rates of unbalanced sperm and embryos: a case report. Prenat Diagn. 2008;28(1):36–41.
Otani T, Roche M, Mizuike M, Colls P, Escudero T, Munné S. Preimplantation genetic diagnosis significantly improves the pregnancy outcome of translocation carriers with a history of recurrent miscarriage and unsuccessful pregnancies. Reprod Biomed Online. 2006;13(6):869–74.
Stephenson MD, Goddijn M. A critical look at the evidence does not support PGD for translocation carriers with a history of recurrent losses. Fertil Steril. 2011;95(1):e1.
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Recurrent biochemical pregnancy after ICSI with sperm from an oligozoospermic man with reciprocal translocation t(18;21)(p11;q21), suggested the translocation as reason of oligozoospermia and ICSI failure.
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Gu, L., Zhang, H. & Zhu, G. Impact of reciprocal translocation t (18; 21) on male infertility and embryo development: lessons from an oocyte-donating ICSI cycle. J Assist Reprod Genet 28, 603–605 (2011). https://doi.org/10.1007/s10815-011-9558-0
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DOI: https://doi.org/10.1007/s10815-011-9558-0