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Is sperm dna damage associated with IVF embryo quality? A systematic review

  • Armand Zini
  • Wael Jamal
  • Lisa Cowan
  • Naif Al-Hathal
Gamete Biology

Abstract

Purpose

Sperm DNA damage is common amongst infertile men and may adversely impact natural reproduction, IUI-assisted reproduction and to a lesser degree IVF pregnancy. The objective of this study was to examine the influence of sperm DNA damage on embryo quality and/or development at IVF and ICSI.

Methods

We conducted a systematic review of studies that evaluated sperm DNA damage and embryo development and/or quality after IVF and/or ICSI.

Results

We identified 28 studies (8 IVF, 12 ICSI and 8 mixed IVF-ICSI studies) that evaluated the relationship between sperm DNA damage and embryo quality. These 28 studies evaluated 3226 treatment cycles (1033 IVF and 873 ICSI, 1320 mixed IVF-ICSI cycles) and demonstrated highly variable characteristics. In 11 of the 28 studies (1/8 IVF, 5/12 ICSI and 5/8 mixed IVF-ICSI studies), sperm DNA damage was associated with poor embryo quality and/or development, whereas the remaining 17 studies showed no relationship between sperm DNA damage and embryo quality and/or development.

Conclusions

This systematic review indicates that the evaluable studies are heterogeneous and that overall, there is no consistent relationship between sperm DNA damage and embryo quality and/or development. The data also suggest that the influence of sperm DNA damage on embryo quality/development may be more significant in ICSI compared to IVF cycles.

Keywords

Spermatozoa Sperm DNA Embryo Pregnancy In vitro fertilization 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Armand Zini
    • 1
    • 5
  • Wael Jamal
    • 2
    • 3
  • Lisa Cowan
    • 4
  • Naif Al-Hathal
    • 1
  1. 1.Division of Urology, Department of SurgeryMcGill UniversityMontrealCanada
  2. 2.Department of Obstetrics and GynecologyUniversity of MontrealMontrealCanada
  3. 3.OVO Fertility ClinicMontrealCanada
  4. 4.The Victoria Fertility CentreVictoriaCanada
  5. 5.St. Mary’s HospitalMontrealCanada

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