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Journal of Assisted Reproduction and Genetics

, Volume 28, Issue 2, pp 129–136 | Cite as

Correlation between embryological factors and pregnancy rate: development of an embryo score in a cryopreservation programme

  • Miquel SoléEmail author
  • Josep Santaló
  • Ignacio Rodríguez
  • Montse Boada
  • Buenaventura Coroleu
  • Pere N. Barri
  • Anna Veiga
Assisted Reproduction Technologies

Abstract

Purpose

To establish which embryo parameters, in frozen thawed embryo transfers, have the highest prognosis value in the establishment of pregnancy. The relative importance of different embryo parameters is used to develop an embryo score.

Methods

Retrospective analysis of the implantation rate in 356 frozen/thawed single embryo transfers. A logistic regression model is used to establish an embryo score.

Results

A direct correlation is established between the implantation rate and fresh embryo development (number of blastomeres and their symmetry), survival rate after thawing and mitosis resumption after overnight culture.

Conclusions

An embryo score is developed to determine the implantation potential of frozen/thawed embryos.

Keywords

Cryopreserved embryos Single embryo transfer Embryological parameters Embryo score 

Notes

Acknowledgements

The authors wish to thank the members of the Servei de Medicina de la Reproducció of Institut Universitari Dexeus in Barcelona for providing clinical and embryological data essential for the development of this study. This work was done under the auspices of the Catedra d’Investigacio en Obstetricia i Ginecologia.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Miquel Solé
    • 1
    Email author
  • Josep Santaló
    • 2
  • Ignacio Rodríguez
    • 3
  • Montse Boada
    • 1
  • Buenaventura Coroleu
    • 1
  • Pere N. Barri
    • 1
  • Anna Veiga
    • 1
    • 4
  1. 1.Servei de Medicina de la Reproducció, Departament d’Obstetrícia, Ginecologia i ReproduccióInstitut Universitari DexeusBarcelonaSpain
  2. 2.Departament de Biologia Cel·lularUniversitat Autònoma de BarcelonaBarcelonaSpain
  3. 3.Unitat de Bioestadística, Departament d’Obstetrícia, Ginecologia i ReproduccióInstitut Universitari DexeusBarcelonaSpain
  4. 4.Banc de Línies Cel.lularsCentre de Medicina Regenerativa de BarcelonaBarcelonaSpain

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