Journal of Assisted Reproduction and Genetics

, Volume 28, Issue 1, pp 85–90 | Cite as

Association between genetic polymorphisms in androgen receptor gene and the risk of preeclampsia in Korean women

  • Ji Hyae Lim
  • ShinYoung Kim
  • Si Won Lee
  • So Yeon Park
  • Jung Yeol Han
  • Jin Hoon Chung
  • Moon Young Kim
  • Jae Hyug Yang
  • Hyun Mee Ryu



To investigate associations between the androgen receptor (AR) polymorphisms as CAG repeats, GGC repeats and c.211G>A polymorphism and the risk of preeclampsia.


The AR polymorphisms were experienced in 184 preeclamptic patients and 190 normal pregnancies and analyzed by multiple logistic regression.


Women with GGC repeats>16 were more frequently observed in preeclampsia, compared to those with GGC repeats≤16 [adjOR (95% CI): 3.64 (1.71–6.23)]. However, no significant differences were observed between the two groups with respect to CAG repeats. The genotypic and allelic frequencies of c.211G>A variant were significantly higher in cases than in controls (P < 0.05 for both). In the combined distribution of these polymorphisms, the highest risk of preeclampsia was found among women with the haplotype as CAG > 20/GA/GGC>16 [adjOR (95% CI): 4.26 (1.92–12.23)].


Our findings suggest that longer GGC repeats and c.211G>A variant in the AR gene are associated with increased susceptibility to the risk of preeclampsia.


Androgen receptor CAG repeats GGC repeats c.211G>A polymorphism Preeclampsia 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ji Hyae Lim
    • 1
  • ShinYoung Kim
    • 1
  • Si Won Lee
    • 2
  • So Yeon Park
    • 1
  • Jung Yeol Han
    • 2
  • Jin Hoon Chung
    • 2
  • Moon Young Kim
    • 2
  • Jae Hyug Yang
    • 2
  • Hyun Mee Ryu
    • 1
    • 2
  1. 1.The Laboratory of Medical Genetics, Medical Research InstituteCheil General Hospital and Women’s Healthcare CenterSeoulSouth Korea
  2. 2.Department of Obstetrics and Gynecology, Cheil General Hospital & Women’s Healthcare CenterKwanDong University School of MedicineSeoulSouth Korea

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