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Journal of Assisted Reproduction and Genetics

, Volume 28, Issue 1, pp 85–90 | Cite as

Association between genetic polymorphisms in androgen receptor gene and the risk of preeclampsia in Korean women

  • Ji Hyae Lim
  • ShinYoung Kim
  • Si Won Lee
  • So Yeon Park
  • Jung Yeol Han
  • Jin Hoon Chung
  • Moon Young Kim
  • Jae Hyug Yang
  • Hyun Mee Ryu
Genetics

Abstract

Purpose

To investigate associations between the androgen receptor (AR) polymorphisms as CAG repeats, GGC repeats and c.211G>A polymorphism and the risk of preeclampsia.

Methods

The AR polymorphisms were experienced in 184 preeclamptic patients and 190 normal pregnancies and analyzed by multiple logistic regression.

Results

Women with GGC repeats>16 were more frequently observed in preeclampsia, compared to those with GGC repeats≤16 [adjOR (95% CI): 3.64 (1.71–6.23)]. However, no significant differences were observed between the two groups with respect to CAG repeats. The genotypic and allelic frequencies of c.211G>A variant were significantly higher in cases than in controls (P < 0.05 for both). In the combined distribution of these polymorphisms, the highest risk of preeclampsia was found among women with the haplotype as CAG > 20/GA/GGC>16 [adjOR (95% CI): 4.26 (1.92–12.23)].

Conclusions

Our findings suggest that longer GGC repeats and c.211G>A variant in the AR gene are associated with increased susceptibility to the risk of preeclampsia.

Keywords

Androgen receptor CAG repeats GGC repeats c.211G>A polymorphism Preeclampsia 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ji Hyae Lim
    • 1
  • ShinYoung Kim
    • 1
  • Si Won Lee
    • 2
  • So Yeon Park
    • 1
  • Jung Yeol Han
    • 2
  • Jin Hoon Chung
    • 2
  • Moon Young Kim
    • 2
  • Jae Hyug Yang
    • 2
  • Hyun Mee Ryu
    • 1
    • 2
  1. 1.The Laboratory of Medical Genetics, Medical Research InstituteCheil General Hospital and Women’s Healthcare CenterSeoulSouth Korea
  2. 2.Department of Obstetrics and Gynecology, Cheil General Hospital & Women’s Healthcare CenterKwanDong University School of MedicineSeoulSouth Korea

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