Abstract
Purpose
To describe a unique case of MZ dichorionic twins and MZ monochorionic triplets in a quintuplet gestation after intracytoplasmatic sperm injection (ICSI) and blastocyst transfer.
Methods
Case report. A 24-year-old woman underwent ICSI and received two blastocysts transferred. A quintuplet gestation was established .Transvaginal ultrasonography was performed sequentially during early pregnancy.
Results
Three intrauterine gestational sacs were revealed at about 5th week. At the 7th week, five gestational sacs presenting heart beats were detected and a quintuplet pregnancy consisting of two monozygotic (MZ) dichorionic twins and three MZ monochorionic triplets was determined. At the 10th week, a single gestational sac with heart beats was detected. The prenatal course was uneventful. A healthy baby was born at 36th week.
Conclusion
Few other reports have described the occurrence of a quintuplet gestation after the transfer of two blastocysts generated by ICSI. Our case is unique in that the two blastocysts underwent two different splitting processes, which occurred possibly at a similar time giving rise to MZ dichorionic twins and MZ monochorionic triplets.
References
Jones GM, Trounson AO. Blastocyst stage transfer: pitfalls and benefits. Hum Reprod. 1999;14:1405–8.
Rijnders PM, van Os HC, Jansen CAM. Increased incidence of monozygotic twinning following the transfer of blastocysts in human IVF/ICSI. Fertil Steril. 1998;70:S16–7.
Wright V, Schieve LA, Vahratian A, Reynolds MA. Monozygotic twinning associated with day 5 embryo transfer in pregnancies conceived after IVF. Hum Reprod. 2004;19:1831–6.
Knopman J, Krey LC, Lee J, Fino ME, Novetsky A, Noyes N. Monozygotic twinning: an eight-year experience at a large IVF center. Fertil Steril 2009; Epub ahead of print.
Slotnik RN, Ortega JE. Monoamniotic twinning and zona manipulation: a survey of U.S. IVF centers correlating zona manipulation procedures and high-risk twinning frequency. J Assist Reprod Genet. 1996;13:381–5.
Hershlag A, Paine T, Cooper GW, Scholl GM, Rawlinson K, Kvapil G. Monozygotic twinning associated with mechanical assisted hatching. Fertil Steril. 1999;71:144–6.
Abusheikha N, Salha O, Sharma V, Brisden P. Monozygotic twinning and IVF/ICSI treatment a report of 11 cases and review of literature. Hum Reprod Update. 2000;6:396–403.
Tarlatzis BC, Qublan HS, Sanopoulus T, Zepiridis L, Grimbizis G, Bontis J. Increase in the monozygotic twinning rate fater intracytoplasmatic sperm injection and blastocyst stage embryo transfer. Fertil Steril. 2002;77:96–198.
Unger S, Hoopmann M, Bald R, Foth D, Nawroth F. Monozygotic triplets and monozygotic twins after ICSI and transfer of two blastocysts: case report. Hum Reprod. 2004;19:110–3.
Hall JG. Twinning. Lancet. 2003;362:735–43.
Gardner DK, Schoolcraft WB. In vitro culture of human blastocysts. In: Jansen R, Mortimer D, editors. Towards reproductive certainty: fertility and genetics beyond 1999: the plenary proceedings of the 11th World Congress of In vitro Fertilization and Human Reproductive genetics. Pearl River: Panthenon; 1999. p. 378–88.
Derom C, Vlietinck R, Derom R, Van den Berghe H, Thiery M. Increased monozygotic twinning rate after ovulation induction. Lancet. 1987;1:1236–8.
Satio H, Tsutumi O, Noda Y, Ibuki Y, Hiroi M. Do assisted reproductive technologies have effects on the demography of monozygotic twinning. Fertil Steril. 2000;74:178–9.
Da Costa AL, Abdelmassih S, de Oliveira FG, Abdelmassih V, Abdelmassih R, Nagy ZP, et al. Monozygotic twins and the transfer of blastocyst after ICSI. Hum Reprod. 2001;16:333–6.
Zikopoulus Z, Platteau P, Kolibianakis E, Albano C, Van Steirteghem A, Devroey P. Quintuplet pregnancy following transfer of two blastocysts: Case report. Hum Reprod. 2004;19:325–7.
Hirata T, Osuga Y, Figimoto A, Oishi H, Hiroi H, Fujiwara T, et al. Conjoined twins in a triplet pregnancy after intracytoplasmic sperm injection and blastocyst transfer: case report and review of the literature. Fertil Steril. 2009;91:933.e9–12.
Menezo YJ, Sakkas D. Monozygotic twinning: is it related to apoptosis in the embryo. Hum Reprod. 2002;17:247–48.
Sills ES, Moomjy M, Zaninovic N, Veeck LL, Mc Gee M, Palermo GD, et al. Human zona pellucid micromanipulation and monozygotic twinning frequency after IVF. Hum Reprod. 2000;15:800–95.
Schachter M, Raziel A, Friedler S, Starssburger D, Bern O, Ron-El R. Monozygotic twinning after assisted reproductive technologies: a phenomenon independent of micromanipulation. Hum Reprod. 2001;16:1264–9.
Verpoest W, Van Landuyt L, Desmyttere S, Cremers A, Devroey P, Liebaers I. The incidence of monozygotic twinning following PGD is not increased. Hum Reprod. 2009;24:2945–50.
Sharara FI, Abdo G. Incidence of monozygotic twins in blastocyst and cleavage stage assisted reproductive technology cycles. Fertil Steril 2009, in press.
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Capsule A case is reported on the birth of MZ dichorionic twins and monochorionic triplets after ICSI and embryo transfer.
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Ferreira, M., Bos-Mikich, A., Höher, M. et al. Dichorionic twins and monochorionic triplets after the transfer of two blastocysts. J Assist Reprod Genet 27, 545–548 (2010). https://doi.org/10.1007/s10815-010-9446-z
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DOI: https://doi.org/10.1007/s10815-010-9446-z