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The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract

  • GENETICS
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Abstract

Purpose

This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.

Methods

Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.

Results

Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The number of trinucleotide repeats does not have an influence on reproductive outcome when adjusted for age, BMI, basal FSH values, parity, infertility status and male or female affected. Cox regression analysis indicates that cumulative live birth rate is not influenced by the number of trinucleotide repeats. The only factor with a significant effect is age (p < 0.05).

Conclusion

There is no evidence of an effect of trinucleotide repeat length on reproductive outcome in patients undergoing ICSI and PGD.

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Acknowledgements

The authors thank the clinical, laboratory, technical, nursing and secretarial staff at the Centres for Reproductive Medicine and Medical Genetics at UZ Brussel.

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Authors and Affiliations

  1. Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium

    Willem Verpoest, Michel De Vos & Paul Devroey

  2. Department of Embryology and Genetics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium

    Sara Seneca, Karen Sermon & Martine De Rycke

  3. Centre for Medical Genetics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium

    Marjan De Rademaeker & Ingeborg Liebaers

  4. Centre for Outcomes Research and Laboratory for Experimental Surgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium

    Patrick Haentjens

Authors
  1. Willem Verpoest
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  2. Sara Seneca
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  3. Marjan De Rademaeker
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  4. Karen Sermon
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  5. Martine De Rycke
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  6. Michel De Vos
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  7. Patrick Haentjens
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  8. Paul Devroey
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  9. Ingeborg Liebaers
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Corresponding author

Correspondence to Willem Verpoest.

Additional information

Capsule

The number of CTG repeats in myotonic dystrophy type 1 (DM1) is not correlated with the reproductive outcome of ICSI and PGD.

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Verpoest, W., Seneca, S., De Rademaeker, M. et al. The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract. J Assist Reprod Genet 27, 327–333 (2010). https://doi.org/10.1007/s10815-010-9392-9

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  • DOI: https://doi.org/10.1007/s10815-010-9392-9

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