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No association of TAP1 and TAP2 genes polymorphism with risk of cervical cancer in north Indian population

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Abstract

Background

Transporter associated with antigen processing (TAP), a member of the ATP-binding cassette transporter super family, is composed of two integral membrane proteins, TAP-1 and TAP-2. The TAP gene product is involved in the processing of endogenous peptides that bind to MHC class I molecules. Mutations and/or polymorphism within these genes could alter the efficacy of the immune response which might be relevant for the development of autoimmune diseases and cancer.

Methods

DNA was isolated from peripheral blood sample of 200 patients with cervical cancer and 200 healthy controls. TAP1 and TAP2 allele polymorphism were determined by polymerase chain reaction.

Result

Significant protective OR (OR = 0.22 95% CI = 0.09–0.51, P < 0.001-OR = 0.47, 95% CI = 0.24–0.92, P = 0.02) was observed for GG and combined AG+GG genotypes of TAP2 in patients with SCC respectively. Similarly, such genotypes (GG, AG+GG) appeared same OR for patient with cervical cancer in study group (OR = 0.12, 95% CI = 0.04–0.39-P < 0.001-OR = 0.5 ,95% CI = 0.25–0.95-P = 0.03). There was decrease risk of cervical cancer in user of oral contraceptive with AG and GG genotypes of TAP2 (OR = 0.55, 95% Cl = 0.41–0.73, P = 0.002, OR = 0.09, 95% CI = 0.02–0.36, P < 0.001) respectively. In case of TAP1 gene all allelic polymorphisms showed a decrease OR in patients with cervical cancer in passive smokers and user of oral contraceptives, though, no significant

Conclusion

Thus, TAP1 and TAP2 genes polymorphism are not linked to cervical carcinoma, since no association was found between a particular genotype and the disease.

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Acknowledgments

The authors are grateful to University Grant Commission (UGC) -New Delhi, India, and University of Sistan and Baluchistan-Zahedan, Iran, for supporting this project financially.

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Authors and Affiliations

  1. Department of Biology, Sistan and Baluchistan University, Zahedan, Iran

    Dor Mohammad Kordi Tamandani

  2. Department of Biotechnology, Panjab University, Chandigrah, India

    Dor Mohammad Kordi Tamandani, Ranbir Chander Sobti, Mohammad Shekari & Seyd Ali Husseini

  3. Department of Genetic, Hormozgan University of Medical Sciences, Bandarabbas, Iran

    Mohammad Shekari

  4. Department of Obstetrics & Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigrah, India

    Vanita Suri

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  1. Dor Mohammad Kordi Tamandani
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  2. Ranbir Chander Sobti
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Correspondence to Dor Mohammad Kordi Tamandani.

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Kordi Tamandani, D.M., Sobti, R.C., Shekari, M. et al. No association of TAP1 and TAP2 genes polymorphism with risk of cervical cancer in north Indian population. J Assist Reprod Genet 26, 173–178 (2009). https://doi.org/10.1007/s10815-009-9301-2

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  • DOI: https://doi.org/10.1007/s10815-009-9301-2

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