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Familial associations between polycystic ovarian syndrome and common diseases

  • PHYSIOLOGY
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The goal of this study was focused on two subjects. First, to determine possible association between PCOS and family history of breast cancer, ovarian cancer, endometrial cancer, heart attack, thrombosis, diabetes and cardiovascular disease (CVD). Second, to evaluate maternal and paternal transmission in PCOS patients with positive family history of a disease.

Methods

A cross-sectional study was conducted in 549 infertile women (273 with PCOS and 276 controls) in Arash hospital of Tehran, Iran, between 2007 and 2008 by using questionnaire.

Results

In this analysis, there were significantly increased number of women with the positive family history of diabetes among PCOS group (28.21% vs. 19.20%, p = 0.01). Meanwhile, four women in PCOS group had self history of diabetes while no one in the control group reported diabetes. A statistically significant positive family history of breast cancer was found among the control group (4.35% vs. 1.30%, p = 0.02). Endometrial cancer and diabetes were observed in mother or mother’s side of the family but heart attack and thrombosis manifested in father or father’s side of the family more. There were no statistically significant differences in a positive individual or family history of ovarian cancer, endometrial cancer, heart attack, thrombosis and CVD between the two groups.

Conclusion

In the present study, women and their relatives with PCOS had an increased prevalence of diabetes and it is more common in mother’s side of the family.

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Acknowledgment

This research has been supported by Tehran University of Medical Sciences and we would like to thank the staff of Arash Hospital for their cooperation throughout the stages of the study.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Roointan Arash women’s Health Research and Educational Hospital, Tehran University of Medical Sciences, Rashid Ave, Tehran, Iran

    Ashraf Moini & Bita Eslami

  2. Department of Endocrinology and Female Infertility, Royan Institute, Tehran, Iran

    Ashraf Moini

Authors
  1. Ashraf Moini
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  2. Bita Eslami
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Corresponding author

Correspondence to Ashraf Moini.

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Capsule

In the present study, women and their relatives with PCOS had an increased prevalence of diabetes and it is more common in mother’s side of the family.

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Moini, A., Eslami, B. Familial associations between polycystic ovarian syndrome and common diseases. J Assist Reprod Genet 26, 123–127 (2009). https://doi.org/10.1007/s10815-009-9297-7

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  • DOI: https://doi.org/10.1007/s10815-009-9297-7

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