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Aneuploidy in abortuses following IVF and ICSI

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Abstract

Purpose

To compare aneuploidy rates in first trimester pregnancy losses following IVF ± ICSI.

Methods

A retrospective cohort analysis of karyotypes of abortuses following conventional IVF (n = 159) and ICSI (n = 196).

Results

50.1% of losses were found to be cytogenetically abnormal among all patients undergoing IVF ± ICSI. A significant increase in fetal aneuploidy rate was noted with increasing maternal age (<30 years = 26.1% vs. 31 to 34 years. = 38.2% vs. 35 to 39 years. = 51.3% vs. >39 years. = 65.9%). Aneuploidy rates were similar in the ICSI vs. conventional IVF groups (52.6% vs. 47.2% [p 0.31, RR 1.11, 95% CI 0.90, 1.38]). More sex chromosome anomalies were noted in the ICSI group.

Conclusions

The aneuploidy rate in first trimester abortuses significantly increases with increasing maternal age. ICSI was not shown to significantly increase the aneuploidy rate. However, more sex chromosome anomalies were found among pregnancies resulting from ICSI.

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Authors and Affiliations

  1. Resident, New Jersey Medical School, UMDNJ, Dept. of Obstetrics, Gynecology and Women’s Health, MSB E-506, 185 South Orange Avenue, Newark, NJ, 07101-1709, USA

    Vitaly A. Kushnir

  2. Robert Wood Johnson Medical School, UMDNJ, Dept. of Obstetrics, Gynecology and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, New Brunswick, NJ, USA

    John L. Frattarelli

  3. Reproductive Medicine Associates of New Jersey, Morristown, NJ, USA

    John L. Frattarelli

Authors
  1. Vitaly A. Kushnir
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  2. John L. Frattarelli
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Correspondence to Vitaly A. Kushnir.

Additional information

Capsule

First trimester abortuses following conventional IVF and ICSI had similar aneuploidy rates. More sex chromosome anomalies were found among pregnancy losses resulting from ICSI.

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Kushnir, V.A., Frattarelli, J.L. Aneuploidy in abortuses following IVF and ICSI. J Assist Reprod Genet 26, 93–97 (2009). https://doi.org/10.1007/s10815-009-9292-z

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  • DOI: https://doi.org/10.1007/s10815-009-9292-z

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