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A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in Ukraine

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Abstract

Purpose

To evaluate the association between phenotype and follicle stimulating hormone receptor (FSHR) genotype in women with ovarian dysfunction and patients with “poor response” to gonadotropin stimulation of ovulation.

Methods

FSHR gene SNPs were analyzed by PCR and RFLP. “Poor responders” (ovarian dysfunction) group and “good responders” group constituted the study group. Normo-ovulatory women who gave birth to naturally conceived children formed control groups: under 35 years of age (control I) and over 35 years of age (control II).

Results

The frequency of Ala307-Ser680/Ala307-Ser680 genotype was significantly more prevalent in the ovarian dysfunction group (26%) compared to the control I (7.7%) (P < 0.001) and a “good responders” group (12.5%) (P < 0.05); and in a “poor responders” group (33.3%) compared to a “good responders” group (P < 0.05), control I (P < 0.001) and control II (17.5%) (P < 0.05).

Conclusions

Our data shows the prevalence of the Ala307-Ser680/ Ala307-Ser680 genotype in the both groups of patients. The finding should have impact on the delineation of stimulation protocols.

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Acknowledgments

We thank the staff at the clinic ISIDA and clinic NADIJA for their kind assistance in collecting the blood samples.

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Correspondence to Ludmila Livshits.

Additional information

FSHR receptor gene polymorphisms and diminished ovarian reserve.

Capsule The association between phenotype and Asn680Ser and Thr307Ala FSHR gene polymorphisms was found in women with ovarian dysfunction and poor response to FSH ovarian stimulation.

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Livshyts, G., Podlesnaja, S., Kravchenko, S. et al. A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in Ukraine. J Assist Reprod Genet 26, 29–34 (2009). https://doi.org/10.1007/s10815-008-9279-1

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  • DOI: https://doi.org/10.1007/s10815-008-9279-1

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