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Molecular analysis of the β-catenin gene in patients with the Mayer-Rokitansky-Küster-Hauser syndrome

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Abstract

Purpose

To study the β-catenin gene in a group of Mayer-Rokitansky-Küster-Hauser patients.

Methods

Twelve patients with the Mayer-Rokitansky-Küster-Hauser syndrome were included in this study. DNA was extracted from peripheral blood and the region codifying β-catenin GSK-3β phosphorylation sites on exon 3 was amplified. PCR products were purified and directly sequenced.

Results

No mutations were found in the GSK-3β phosphorylation sites on exon 3 of β-catenin gene in this group of patients with the MRKH syndrome.

Conclusions

β-catenin gene mutations are an unlikely cause of the MRKH syndrome.

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Acknowledgement

This work was partially supported by FAPEMIG and CNPq (#473169/2004-5), Brasil.

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Authors and Affiliations

  1. Department of Pharmacology, Federal University of Minas Gerais (UFMG), R. Vitório Marçola, 859/801, Belo Horizonte, 30310-360, Brazil

    Juliana B. Drummond, Joana S. Carvalho & Luiz De Marco

  2. Department of Gynecology and Obstetrics, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil

    Camila F. Rezende, Fabio C. Peixoto & Fernando M. Reis

Authors
  1. Juliana B. Drummond
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  2. Camila F. Rezende
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  3. Fabio C. Peixoto
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  4. Joana S. Carvalho
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  5. Fernando M. Reis
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  6. Luiz De Marco
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Corresponding author

Correspondence to Juliana B. Drummond.

Additional information

Capsule β-catenin gene mutations were not detected in a group of twelve patients with the Mayer-Rokitansky Küster-Hauser (MRKH) anomaly.

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Drummond, J.B., Rezende, C.F., Peixoto, F.C. et al. Molecular analysis of the β-catenin gene in patients with the Mayer-Rokitansky-Küster-Hauser syndrome. J Assist Reprod Genet 25, 511–514 (2008). https://doi.org/10.1007/s10815-008-9261-y

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  • DOI: https://doi.org/10.1007/s10815-008-9261-y

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