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Interval double transfer improves treatment success in patients with repeated IVF/ET failures

  • Assisted Reproduction
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To examine whether double transfer of embryos on day 2–3 and on day 5 after ovum pick-up (OPU) improves IVF/ET success rates in patients with multiple consecutive IVF failures

Methods

Consecutive IVF failures patients (7.6 ± 0.5) undergoing IVF/ET cycles were treated with interval double transfer on day 2–3 and on day 5 after OPU. Matched patients, that had embryos transferred only once on day 2 or 3 served as controls.

Results

Baseline and cycle characteristics were similar in the study group and controls. The total pregnancy rate was 44.6% in the study group and 24.2% in the controls (p = 0.001), and the clinical pregnancy rates were 38.5% and 19.6%, respectively (p = 0.001).

Conclusions

Patients with multiple consecutive IVF/ET failures, treated with the interval double transfer approach had significantly improved cycle success rates compared with regular day 2 or 3 embryo transfer protocol.

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Acknowledgment

Tatyana Cohen and Ariela Carmon from IVF laboratory and Esther Eshkol is thanked for editorial assistance.

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Authors and Affiliations

  1. Sarah Racine IVF Unit, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Center, 6 Weizmann Street, Tel-Aviv, 64239, Israel

    B. Almog, I. Wagman, R. Kapustiansky, T. Schwartz, N. Mey-Raz, A. Amit & F. Azem

  2. Department of Gynecology, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    I. Levin

Authors
  1. B. Almog
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  2. I. Levin
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  3. I. Wagman
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  4. R. Kapustiansky
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  5. T. Schwartz
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  6. N. Mey-Raz
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  7. A. Amit
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  8. F. Azem
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Corresponding author

Correspondence to B. Almog.

Additional information

Capsule Patients with consecutive repeated IVF/ET failures, treated with the interval double transfer had significantly improved cycle success rates compared with regular day 3 embryo transfer.

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Almog, B., Levin, I., Wagman, I. et al. Interval double transfer improves treatment success in patients with repeated IVF/ET failures. J Assist Reprod Genet 25, 353–357 (2008). https://doi.org/10.1007/s10815-008-9237-y

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  • DOI: https://doi.org/10.1007/s10815-008-9237-y

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