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Elevated body mass index (BMI) does not adversely affect in vitro fertilization outcome in young women

  • Assisted Reproduction
  • Published:
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Abstract

Objective

To determine if elevated body mass index in young women with normal ovarian reserve was associated with poorer ovarian response, difficulty at embryo transfer, and lower clinical pregnancy rates.

Materials and methods

Retrospective study of 417 first, fresh in vitro fertilization cycles performed between October 2004 and December 2006. All women were under the age of 35 and had normal cycle day 3 follicle stimulating hormone and estradiol levels. Subjects were divided into groups by BMI: <18.5, 18.5–24.9, 25–29.9, ≥30.

Results

Cancellation rates, peak estradiol levels, and mean number of oocytes retrieved were similar in all groups. There was a trend toward increasing difficulty in visualizing the air bubble at time of embryo transfer and lower implantation rates at higher body mass indices. Clinical and ongoing pregnancy rates were similar among groups.

Conclusion

Obesity in young women does not adversely affect clinical pregnancy rates in patients treated with in vitro fertilization.

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References

  1. Bolumar F, Olsen J, Rebagliato M, Saez-Lloret I, Bisanti L. Body mass index and delayed conception: a European Multicenter Study on Infertility and Subfecundity. Am J Epidemiol 2000;151:1072–9.

    PubMed  CAS  Google Scholar 

  2. Diamanti-Kandarakis E, Bergiele A. The influence of obesity on hyperandrogenism and infertility in the female. Obes Rev 2001;2:231–8.

    Article  PubMed  CAS  Google Scholar 

  3. Poretsky L, Cataldo NA, Rosenwaks Z, Guidice LC. The insulin-related ovarian regulatory system in health and disease. Endocr Rev 1999;20:535–82.

    Article  PubMed  CAS  Google Scholar 

  4. Wang JX, Davies M, Norman RJ. Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study. BMJ 2000;321:1320–1.

    Article  Google Scholar 

  5. Gonzalez F, Rote NS, Minium J, Kirwan JP. Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J Clin Endocrinol Metab 2006;91:336–40.

    Article  PubMed  CAS  Google Scholar 

  6. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005;3:28–49.

    Article  PubMed  CAS  Google Scholar 

  7. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TM, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334(5):292–5.

    Article  PubMed  CAS  Google Scholar 

  8. Agarwal SK, Vogel K, Weitsman SR, Magoffin DA. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J Clin Endocrinol Metab 1999;84:1072–6.

    Article  PubMed  CAS  Google Scholar 

  9. Lobo RA, Gysler M, March CM, Goebelsmann U, Mishell Jr DR. Clinical and laboratory predictors of clomiphene response. Fertil Steril 1982;37:168–74.

    PubMed  CAS  Google Scholar 

  10. Shepard MK, Balmaceda JP, Lecia CG. Relationship of weight to successful induction of ovulation with clomiphene citrate. Fertil Steril 1979;32:641–5.

    PubMed  CAS  Google Scholar 

  11. Dickey RP, Taylor SN, Curole DN, Rye PH, Lu PY, Pyrzak R. Relationship of clomiphene dose and patient weight to successful treatment. Hum Reprod 1997;12:449–53.

    Article  PubMed  CAS  Google Scholar 

  12. Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkamph MP, Coutifaris C, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Giudice LC, Leppert PC, Myers ER. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med 2007;356(6):551–66.

    Article  PubMed  CAS  Google Scholar 

  13. Balen AH, Platteau P, Andersen AN, Devroey P, Sorensen P, Helmgaard L, Arce JC. The influence of body weight on response to ovulation induction with gonadotrophins in 335 women with World Health Organization group II anovulatory infertility. BJOG Int J Obstet Gynaecol 2006;113:1195–202.

    Article  CAS  Google Scholar 

  14. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81(1):19–25.

    Article  Google Scholar 

  15. Luna M, Grunfeld L, Mukherjee T, Sandler B, Copperman AB. Moderately elevated levels of basal follicle-stimulating hormone in young patients predict low ovarian response, but should not be used to disqualify patients from attempting in vitro fertilization. Fertil Steril 2007;87(4):782–7.

    Article  PubMed  CAS  Google Scholar 

  16. Brown JA, Buckingham K, Abou-Setta A, Buckett W. Ultrasound versus ‘clinical touch’ for catheter guidance during embryo transfer in women (Review). Cochrane Database of Systematic Reviews 2007, Issue 1.

  17. Wood EG, Batzer FR, Go KJ, Gutmann JN, Corson SL. Ultrasound-guided soft catheter embryo transfers will improve pregnancy rates in in-vitro fertilization. Hum Reprod 2000;15(1):107–12.

    Article  PubMed  CAS  Google Scholar 

  18. Lintsen AME, Pasker-de Jong PCM, de Boer EJ, Burger CW, Jansen CAM, Braat DDM, van Leeuwen FE. Effects of subfertility cause, smoking and body weight on the success rate of IVF. Hum Reprod 2005;20(7):1867–75.

    Article  PubMed  CAS  Google Scholar 

  19. Nichols JE, Crane MM, Higdon HL, Miller PB, Boone WR. Extremes of body mass index reduce in vitro fertilization pregnancy rates. Fertil Steril 2003;79(3):645–7.

    Article  PubMed  Google Scholar 

  20. Wang JX, Davies M, Norman RJ. Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study. BMJ 2000;321:1320–1.

    Article  PubMed  CAS  Google Scholar 

  21. Styne-Gross A, Elkind-Hirsh K, Scott RT. Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation. Fertil Steril 2005;83(6):1629–34.

    Article  PubMed  Google Scholar 

  22. Spandorfer SD, Kump L, Goldschlag D, Brodkin T, Davis OK, Rosenwaks Z. Obesity and in vitro fertilization: negative influences on outcome. J Reprod Med 2004;49:973–7.

    PubMed  Google Scholar 

  23. Dokras A, Baredziak L, Blaine J, Syrop C, VanVoorhis BJ, Sparks A. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol 2006;108(1):61–9.

    PubMed  Google Scholar 

  24. Fedorcsak P, Dale PO, Storeng R, Ertzeid G, Bjercke S, Oldereid N, Omland AK, Abyholm T, Tanbo T. Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 2004;19(11):2523–8.

    Article  PubMed  Google Scholar 

  25. Dechaud H, Anahory T, Reyftmann L, Loup V, Hamamah S, Hedon B. Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Euro J of Ob/Gyn and Repro Bio 2006;127:88–93.

    Article  Google Scholar 

  26. Lashen H, Ledger W, Bernal AL, Barlow D. Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization. Hum Reprod 1999;14(3):712–5.

    Article  PubMed  CAS  Google Scholar 

  27. Moran LJ, Noakes M, Clifton PM, Tomlinson L, Norman RJ. Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic ovary syndrome. J Clin Endocrinol Metab 2003;88(2):812–9.

    Article  PubMed  CAS  Google Scholar 

  28. Lashen H, Fear K, Sturdee DW. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum Reprod 2004;19:1644–6.

    Article  PubMed  CAS  Google Scholar 

  29. Bellver J, Rossal LP, Bosch E, Zuniga A, Corona JT, Melendez F, Gomez E, Simon C, Remohi J, Pellicer A. Obesity and the risk of spontaneous abortion after oocyte donation. Fertil Steril 2003;79:1136–40.

    Article  PubMed  Google Scholar 

  30. Fedorcsak P, Storeng R, Dale PO, Tanbo T, Abyholm T. Obesity is associated with early pregnancy loss after IVF or ICSI. Acta Obstet Gynecol Scand 2000;79:43–8.

    Article  PubMed  CAS  Google Scholar 

  31. Wang JX, Davies MJ, Norman RJ. Obesity increases the risk of spontaneous abortion during infertility treatment. Obes Res 2002;10:551–4.

    Article  PubMed  Google Scholar 

  32. Weiss JL, Malone FD, Emig D, Ball RH, Nyberg DA, Comstock CH, Saade G, Eddleman K, Carter SM, Craigo SD, Carr SR, D’Alton ME. Obesity, obstetric complications and cesarean delivery rate—a population-based screening study. Am J Obstet Gynecol 2004;190:1091–7.

    Article  PubMed  Google Scholar 

  33. Cnattingius S, Bergstrom R, Lipworth L, Kramer MS. Prepregnancy weight and the risk of adverse pregnancy outcomes. N Engl J Med 1998;338:147–52.

    Article  PubMed  CAS  Google Scholar 

  34. Catalano PM. Management of obesity in pregnancy. Obstet Gynecol 2007;109:419–33.

    PubMed  Google Scholar 

  35. Yu CKH, Teoh TG, Robinson S. Obesity in pregnancy. BJOG 2006;113:1117–25.

    Article  PubMed  CAS  Google Scholar 

  36. Ramsay JE, Greer I, Sattar N. ABC of obesity. Obesity and reproduction. BMJ 2006;333:1159–62.

    Article  PubMed  Google Scholar 

  37. Waller DK, Shaw GM, Rasmussen SA, Hobbs CA, Canfield MA, Siega-Riz AM, Gallaway MS, Correa A; National Birth Defects Prevention Study. Prepregnancy obesity as a risk factor for structural birth defects. Arch Pediatr Adolesc Med 2007;161:745–50.

    Article  PubMed  Google Scholar 

  38. Dixon JB, Dixon ME, O’Brien PE. Birth outcomes in obese women after laparoscopic adjustable gastric banding. Obstet Gynecol 2005;106(5):965–72.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Mt. Sinai Department of Obstetrics, Gynecology and Reproductive Science, 1 Gustave L. Levy Place, New York, NY, 10029, USA

    Kurt Martinuzzi, Sarah Ryan & Alan B. Copperman

  2. Reproductive Medicine Associates of New York, 635 Madison Avenue, New York, NY, 10022, USA

    Martha Luna & Alan B. Copperman

Authors
  1. Kurt Martinuzzi
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  2. Sarah Ryan
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  3. Martha Luna
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  4. Alan B. Copperman
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Corresponding author

Correspondence to Kurt Martinuzzi.

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Capsule

Obesity does not adversely affect clinical pregnancy rates in young women with normal ovarian reserve undergoing their first in vitro fertilization cycle.

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Martinuzzi, K., Ryan, S., Luna, M. et al. Elevated body mass index (BMI) does not adversely affect in vitro fertilization outcome in young women. J Assist Reprod Genet 25, 169–175 (2008). https://doi.org/10.1007/s10815-008-9213-6

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  • DOI: https://doi.org/10.1007/s10815-008-9213-6

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