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Elevated basal FSH levels, if it is under 15 IU/L, will not reflect poor ART outcomes

  • Rieko Kojima
  • Koji Nakagawa
  • Akira Nakashima
  • Takashi Horikawa
  • Shirei Ohgi
  • Hidekazu Saito
Original Paper

Abstract

Purpose

For this study, the impact of basal FSH levels on ART outcomes was assessed.

Methods

From June 2003 to May 2006, 191 ART cycles were performed in our hospital. All cases were treated with GnRH-a long protocol. The patients were classified according to their basal FSH level as follows: group A: FSH < 10 IU/l, group B: 10 ≦ FSH < 15 IU/l, and group C: 15 IU/l ≦ FSH. ART outcomes were compared among the three groups.

Results

The number of retrieved oocytes in group A was significantly higher than in group B, but fertilized oocytes and the pregnancy rates were comparable. The pregnancy rate in group C was not significantly lower than those found in either group A or B, but the trend was lower.

Conclusion

Oocytes retrieved from the patients who showed basal FSH levels below 15 IU/l were found to possess significant pregnancy potential.

Keywords

ART Basal FSH Pregnancy rate 

References

  1. 1.
    Nakahara K, Saito H, Saito T, Ito M, Ohta N, Sakai N, Tezuka N, Hiroi M, Watanabe H. Incidence of apoptotic bodies in membrana granulosa of the patients participating in an in vitro fertilization program. Fertil Steril. 1997;67:302–8.PubMedCrossRefGoogle Scholar
  2. 2.
    Seino T, Saito H, Kaneko T, Takahashi T, Kawachiya S, Kurachi H. Eight-hydroxy-2′-deoxyguanosine in granulosa cells is correlated with the quality of oocytes and embryos in an in vitro fertilization-embryo transfer program. Fertil Steril. 2002;77:1184–90.PubMedCrossRefGoogle Scholar
  3. 3.
    Toya M, Saito H, Ohta N, Saito T, Kaneko T, Hiroi M. Moderate and severe endometriosis is associated with alterations in the cell cycle of granulosa cells in patients undergoing in vitro fertilization and embryo transfer. Fertil Steril. 2000;73:344–50.PubMedCrossRefGoogle Scholar
  4. 4.
    Saito H, Kaneko T, Takahashi T, Kawachiya S, Saito T, Hiroi M. Hyaluronan in follicular fluids and fertilization of oocytes. Fertil Steril. 2000;74:1148–52.PubMedCrossRefGoogle Scholar
  5. 5.
    Nakagawa K, Ozawa N, Takamatsu K, Takahashi Y, Irahara M, Yoshimura Y, Saito H. A reduction in intraovarian arterial blood flow resistance after ovulation is necessary to achieve pregnancy in natural cycle. J Assist Reprod Genet. 2005;22:9–14.PubMedCrossRefGoogle Scholar
  6. 6.
    Nakagawa K, Takahashi Y, Ito M, Horikawa T, Ohgi S, Irahara M, Saito H. Intraovarian arterial blood flow resistance in oligomenorrheal infertile women. J Assist Reprod Genet. 2006;23:105–10.PubMedCrossRefGoogle Scholar
  7. 7.
    Nakagawa K, Ohgi S, Kojima R, Itoh M, Horikawa T, Irahara M, Saito H. Reduction of perifollicular arterial blood flow resistance after hCG administration is a good indicator of the recovery of mature oocytes in ART treatment. J Assist Reprod Genet 2006;23:433–8.PubMedCrossRefGoogle Scholar
  8. 8.
    Muasher SJ, Oehninger S, Simonetti S, Matta J, Ellis LM, Liu HC, Jones GS, Rosenwaks Z. The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome. Fertil Steril. 1988;50:298–307.PubMedGoogle Scholar
  9. 9.
    Lenton EA, Sexton L, Lee S, Cooke ID. Progressive changes in LH and FSH and LH: FSH ratio in women throughout reproductive life. Maturitas. 1988;10:35–43.PubMedCrossRefGoogle Scholar
  10. 10.
    van Rooij IA, Bancsi LF, Broekmans FJ, Looman CW, Habbema JD, te Velde ER. Women older than 40 years of age and those with elevated follicle-stimulating hormone levels differ in poor response rate and embryo quality in in vitro fertilization. Fertil Steril. 2003;79:482–8.PubMedCrossRefGoogle Scholar
  11. 11.
    El-Toukhy T, Khalaf Y, Hart R, Taylor A, Braude P. Young age does not protect against the adverse effects of reduced ovarian reserve—an eight year study. Hum Reprod. 2002;17:1519–24.PubMedCrossRefGoogle Scholar
  12. 12.
    Abdalla H, Thum MY. An elevated basal FSH reflects a quantitative rather than qualitative decline of the ovarian reserve. Hum Reprod. 2004;19:893–8.PubMedCrossRefGoogle Scholar
  13. 13.
    Bancsi LF, Broekmans FJ, Mol BW, Habbema JD, te Velde ER. Performance of basal follicle-stimulating hormone in the prediction of poor ovarian response and failure to become pregnant after in vitro fertilization: a meta-analysis. Fertil Steril. 2003;79:1091–100.PubMedCrossRefGoogle Scholar
  14. 14.
    Nakagawa K, Ohgi S, Kojima R, Sugawara K, Itoh M, Horikawa T, Irahara M, Saito H. Recombinant-FSH has more effective potent than urinary human menopausal gonadotropin in ovarian hyperestimulation for ART treatment. Reprod Med Biol. 2007;6:27–32.CrossRefGoogle Scholar
  15. 15.
    Nakagawa K, Ohgi S, Kojima R, Itoh M, Horikawa T, Irahara M, Saito H. Reduction of perifollicular arterial blood flow resistance after hCG administration is a good indicator of the recovery of mature oocytes in ART treatment. J Assist Reprod Genet. 2006;23:433–8.PubMedCrossRefGoogle Scholar
  16. 16.
    Nakagawa K, Yamano S, Moride N, Yamashita M, Yoshizawa M, Aono T. Effect of activation with Ca ionophore A23187 and puromycin on the development of human oocytes that failed to fertilize after intracytoplasmic sperm injection. Fertil Steril. 2001;76:148–52.PubMedCrossRefGoogle Scholar
  17. 17.
    Surrey ES, Schoolcraft WB. Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques. Fertil Steril. 2000;73:667–76.PubMedCrossRefGoogle Scholar
  18. 18.
    Esposito MA, Coutifaris C, Barnhart KT. A moderately elevated day 3 FSH concentration has limited predictive value, especially in younger women. Hum Reprod. 2002;17:118–23.PubMedCrossRefGoogle Scholar
  19. 19.
    van Rooij IA, de Jong E, Broekmans FJ, Looman CW, Habbema JD, te Velde ER. High follicle-stimulating hormone levels should not necessarily lead to the exclusion of subfertile patients from treatment. Fertil Steril. 2004;81:1478–85.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Rieko Kojima
    • 1
  • Koji Nakagawa
    • 1
  • Akira Nakashima
    • 1
  • Takashi Horikawa
    • 1
  • Shirei Ohgi
    • 1
  • Hidekazu Saito
    • 1
  1. 1.Division of Reproductive Medicine, Department of Perinatal Medicine and Maternal CareNational Center for Child Health and DevelopmentTokyoJapan

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