Abstract
Purpose
To compare the effectiveness of using recFSH commenced in the luteal phase with a long GnRH agonist protocol or in the early follicular phase with a short GnRH agonist protocol, in infertile women designated as poor responders undergoing treatment with assisted reproduction in a prospective, randomized, controlled study.
Materials and methods
Forty-two couples undergoing an ICSI cycle of whom female partner diagnosed as poor responder were included in the study. Recombinant FSH was given daily from day 21 of the previous cycle upon initiation of GnRH agonist in the study group. Control group was given FSH on day 2 in a short protocol GnRH agonist regimen. The number of metaphase 2 oocytes was analysed as the main outcome measure; pregnancy rate and clinical pregnancy rate were secondary outcome measures.
Results
Patients in the study group had significantly higher number of metaphase 2 oocytes. Although not statistically significantly patients in the study group had higher pregnancy/clinical pregnancy rates, as well.
Conclusion
This preliminary study shows that luteal start of recFSH simultaneously with long protocol GnRH agonist in poor responder women produced better results comparing to short protocol GnRH agonist plus high dose FSH regimen.
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Capsule: Luteal administration of recFSH along with GnRHa in poor responder women in an ART cycle increases metaphase 2 oocyte number significantly comparing to GnRHa flare-up protocol
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Kucuk, T., Sozen, E. Luteal start of exogenous FSH in poor responder women. J Assist Reprod Genet 24, 635–638 (2007). https://doi.org/10.1007/s10815-007-9176-z
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DOI: https://doi.org/10.1007/s10815-007-9176-z