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The possible role of hyperhomocysteinemia on IVF outcome

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Abstract

Purpose

To evaluate the effect of the hyperhomocysteinemia on pregnancy rate, implantation rate and abortion rate after IVF.

Method

Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level.

Results

Pregnancy rate, implantation rate and abortion rate varied significantly (p ≤ 0.05) between the two groups. The number and quality of embryos transferred did not differ between the groups.

Conclusion

The results suggest that hyperhomocysteinemia could affect IVF outcome

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Authors and Affiliations

  1. Obstetric and Gynecology, Policlinico Umberto, La Sapienza University of Rome, Viale Regina Elena, Rome, Italy

    Arianna Pacchiarotti, Mohamed A. Mohamed, Giulietta Micara, Antonella Linari, Daniela Tranquilli, Salomè B. Espinola & Cesare Aragona

  2. Praxi Pro Vita Centro di Fertilità, Via Magnagrecia 117, Rome, Italy

    Arianna Pacchiarotti, Mohamed A. Mohamed & Cesare Aragona

Authors
  1. Arianna Pacchiarotti
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  2. Mohamed A. Mohamed
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  3. Giulietta Micara
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  4. Antonella Linari
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  5. Daniela Tranquilli
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  6. Salomè B. Espinola
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  7. Cesare Aragona
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Corresponding author

Correspondence to Arianna Pacchiarotti.

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Pacchiarotti, A., Mohamed, M.A., Micara, G. et al. The possible role of hyperhomocysteinemia on IVF outcome. J Assist Reprod Genet 24, 459–462 (2007). https://doi.org/10.1007/s10815-007-9165-2

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  • DOI: https://doi.org/10.1007/s10815-007-9165-2

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