Abstract
Purpose
To determine the demand and preferences of infertility patients for sex selection for nonmedical reasons, and to investigate the relation between these choices and their demographic and socioeconomic characteristics.
Methods
A cross-sectional, self-administered survey by mail was conducted at a University hospital-based fertility center of 1,350 consecutive women who presented for infertility care, to assess patient demand and preferences for sex selection.
Results
Of respondents, 49% wanted to select the sex of their next child for no added cost. Of these patients, 56% had no living children and 37% had children all of one sex. After adjustment for observed predictors of gender preference, we found a significant preference for a female child among women who had only sons, had more living children, or were single. Nulliparous women did not significantly prefer one sex over the other. Among parous women, those with only daughters significantly desired to select a male child, whereas those with sons significantly desired to select a female child.
Conclusion
There is significant demand among infertility patients for preimplantation sex selection, with a significant portion of this demand coming from patients who do not have any children or have children all of one sex.
Similar content being viewed by others
References
Handyside AH, Pattinson JK, Penketh RJ, Delhanty JD, Winston RM, Tuddenham EG. Biopsy of human preimplantation embryos and sexing by DNA amplification. Lancet 1989;1:347–9.
Handyside AH, Kontogianni EH, Hardy K, Winston RM. Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature 1990;344:768–70.
Soussis I, Harper JC, Handyside AH, Winston RM. Obstetric outcome of pregnancies resulting from embryos biopsied for pre-implantation diagnosis of inherited disease. Br J Obstet Gynaecol 1996;103:784–8.
Johnson LA, Welch GR, Keyvanfar K, Dorfmann A, Fugger EF, Schulman JD. Gender preselection in humans? Flow cytometric separation of X and Y spermatozoa for the prevention of X-linked diseases. Hum Reprod 1993;8:1733–9.
Vidal F, Fugger EF, Blanco J, Keyvanfar K, Catala V, Norton M, et al. Efficiency of MicroSort flow cytometry for producing sperm populations enriched in X- or Y-chromosome haplotypes: a blind trial assessed by double and triple colour fluorescent in-situ hybridization. Hum Reprod 1998;13:308–12.
Fugger EF, Black SH, Keyvanfar K, Schulman JD. Births of normal daughters after microsort sperm separation and intrauterine insemination, in-vitro fertilization, or intracytoplasmic sperm injection. Hum Reprod 1998;13:2367–70.
ESHRE PGD Consortium Steering Committee. ESHRE Preimplantation Genetic Diagnosis Consortium: data collection III (May 2001). Hum Reprod 2002;17:233–46.
Kalb C. Brave new babies. Newsweek. 26 Jan 2004.
Benagiano G, Bianchi P. Sex preselection: an aid to couples or a threat to humanity? Hum Reprod 1999;14:870–2.
Allahbadia GN. The 50 million missing women. J Assist Reprod Genet 2002;19:411–6.
Plafker T. Sex selection in China sees 117 boys born for every 100 girls. BMJ 2002;324:1233.
Sen A. Missing women—revisited. BMJ 2003;327:1297–8.
American College of Obstetrics and Gynecology. Sex selection. In: Ethics in obstetrics and gynecology. Washington, D.C.: ACOG; 2002.
FIGO. Recommendations on ethical issues in obstetrics and gynecology by the FIGO Committee for the Ethical Aspects of Human Reproduction and Women’s Health. London: FIGO, 2000.
The President’s Council on Bioethics. Beyond therapy—biotechnology and the pursuit of happiness. Washington, D.C., October 2003 (Available at http://www.bioethics.gov).
Wade N. Bush’s advisers on biotechnology express concern on its use. The New York Times. 17 Oct 2003.
Human Fertilisation and Embryology Authority. Sex selection: options for regulation. London: HFEA; 2003.
Ethics Committee of the American Society for Reproductive Medicine. Preconception gender selection for nonmedical reasons. Fertil Steril 2001;75:861–4.
Robertson JA. Sex selection for gender variety by preimplantation genetic diagnosis. Fertil Steril 2002;78:463.
Dahl E, Gupta RS, Beutel M, Stoebel-Richter Y, Brosig B, Tinneberg H, et al. Pre-conception sex selection demand and preferences in the United States. Fertil Steril 2006; 85468–73.
Jain T, Missmer SA, Gupta RS, Hornstein MD. Pre-implantation sex selection demand and preferences in an infertility population. Fertil Steril 2005;83:649–58.
Rothman KJ, Greenland S. Modern epidemiology. 2nd ed. Philadelphia: Lippincott-Raven; 1998.
Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health 1989;79:340–9.
Hosmer DW, Lemeshow S. Applied logistic regression. New York: Wiley; 1989.
The Vatican. Catechism of the catholic church. Article 6: The sixth commandment. Available at: http://www.vatican.va/archive/ccc_css/archive/catechism/p3s2c2a6.htm#2377 (Accessed March 1, 2007).
Schenker JG. Assisted reproductive practice: religious perspectives. Reprod Biomed Online 2005;10:310–9.
Schenker JG. Gender selection: cultural and religious perspectives. J Assist Reprod Genet 2002;19:400–10.
Acknowledgement
We thank Neelima Sharma, MD for her assistance with data collection.
Author information
Authors and Affiliations
Corresponding author
Additional information
Financial support: none
Conflict of interest: none
Rights and permissions
About this article
Cite this article
Missmer, S.A., Jain, T. Preimplantation sex selection demand and preferences among infertility patients in Midwestern United States. J Assist Reprod Genet 24, 451–457 (2007). https://doi.org/10.1007/s10815-007-9157-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10815-007-9157-2