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Comparison of c-DNA microarray analysis of gene expression between eutopic endometrium and ectopic endometrium (endometriosis)

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Abstract

Problem: As recent studies have suggested abnormalities in the regulation of specific genes in the development of endometriosis, we investigated differentially expressed genes in endometriosis compared to endometrium. Method of study: Gene expression profiles using the Atlas microarray were performed in endometriotic tissue and endometrium. Nine of the 13 genes of endometriotic tissue showed an up-regulation in relation to endometrium and four of the 13 genes a down-regulation. Results: Of the 1176 genes on the Atlas Human 1,2 array, only 13 differentially expressed identical genes were detected after repeating the gene analysis three times. Conclusion: According to our c-DNA analysis some differentially expressed genes may be involved in the pathogenesis of endometriosis. An imbalance in the genes responsible for the reproductive process may lead to a decrease in embryo implantation in patients with endometriosis.

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Authors and Affiliations

  1. Department of Obstetrics & Gynaecology, University Hospitals Schleswig-Holstein, Campus Kiel, Michaelisstr. 16, 24105, Kiel, Germany

    L. Mettler, A. Salmassi, T. Schollmeyer, A. G. Schmutzler, F. Püngel & W. Jonat

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  1. L. Mettler
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  2. A. Salmassi
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  3. T. Schollmeyer
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  4. A. G. Schmutzler
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  5. F. Püngel
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  6. W. Jonat
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Correspondence to A. Salmassi.

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A. Salmassi equal contribution to the study as first author.

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Mettler, L., Salmassi, A., Schollmeyer, T. et al. Comparison of c-DNA microarray analysis of gene expression between eutopic endometrium and ectopic endometrium (endometriosis). J Assist Reprod Genet 24, 249–258 (2007). https://doi.org/10.1007/s10815-007-9116-y

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  • DOI: https://doi.org/10.1007/s10815-007-9116-y

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