Natural conception after age 45 in Bedouin women, a uniquely fertile population

  • Yuval Gielchinsky
  • Moshe Mazor
  • Alex Simon
  • Shlomo Mor-Yossef
  • Neri LauferEmail author


Purpose: Women conceiving naturally and delivering after age 45 are an exceptionally fertile population that may serve as a model to identify factors associated with delayed reproductive aging. This work studies this phenomenon in Bedouin women. Methods: The study is an observational retrospective analysis of all Bedouin women who conceived spontaneously and had their latest delivery after the age of 45 years, during the years 1995–2000 at the participating medical center. Complete histories of the outcomes of all pregnancies were collected. Results: 133 of 34,519 (0.38%) Bedouin women gave birth after the age of 45 years. The mean maternal age at last delivery was 46±1.4 years (range: 45–52), and the mean parity was 11.6±2.9 children (range: 3–18). 96% were grandmultiparous (≥6 deliveries). The mean spontaneous abortion rate (6.6%) was not affected by increased parity and was significantly lower than in the general population: 12.4% vs.17.7% at age 39, 5% vs. 33.8% (p < 0.001) at age 44 and 1.8% vs. 53.2% (p < 0.001) at age 45. Conclusions: This unique group of Bedouin women may have a genetic predisposition to delayed ovarian and oocyte aging.


Bedouin Maternal age Reproductive aging Spontaneous conception 


  1. 1.
    Klein J, Sauer MV. Assessing fertility in women of advanced reproductive age. Am J Obstet Gynecol 2001;185:758–70PubMedCrossRefGoogle Scholar
  2. 2.
    Tietze C. Reproductive span and rate of reproduction among Hutterite women. Fertil Steril 1957;8:89–97PubMedGoogle Scholar
  3. 3.
    O’Connor KA, Holman DJ, Wood JW. Declining fecundity and ovarian ageing in natural fertility populations. Maturitas 1998;30:127–36PubMedCrossRefGoogle Scholar
  4. 4.
    Wood JW. Fecundity and natural fertility in humans. In: Milligen SR, editor. Oxford Reviews of Reproductive Biology. Oxford: Oxford University Press 1989; 2:61–109Google Scholar
  5. 5.
    Lass A, Croucher C, Duffy S, Dawson K, Margara R, Winston RM. One thousand initiated cycles of in vitro fertilization in women > or = 40 years of age. Fertil Steril 1998;70:1030–4PubMedCrossRefGoogle Scholar
  6. 6.
    Ron-El R, Raziel A, Strassburger D, Schachter M, Kasterstein E, Friedler S. Outcome of assisted reproductive technology in women over the age of 41. Fertil Steril 2000;74:471–5PubMedCrossRefGoogle Scholar
  7. 7.
    Vaskivuo TE, Anttonen M, Herva R, Billig H, Dorland M, te Velde ER, et al. Survival of human ovarian follicles from fetal to adult life: apoptosis, apoptosis-related proteins, and transcription factor GATA-4. J Clin Endocrinol Metab 2001;86:3421–9PubMedCrossRefGoogle Scholar
  8. 8.
    Warburton D, Kline J, Stein Z, Strobino B. Cytogenetic abnormalities in spontaneous abortions of recognized conceptions. In: Porter IH, Willey A (eds), Perinatal Genetics: Diagnosis and Treatment. New York, Academic Press 1986; 133–145Google Scholar
  9. 9.
    Laufer N, Simon A, Samueloff A, Yaffe H, Milwidsky A, Gielchinsky Y. Successful spontaneous pregnancies in women older than 45 years. Fertil Steril 2004;81:1328–32PubMedCrossRefGoogle Scholar
  10. 10.
    The American College of Obstetricians and Gynecologists (2001) Prenatal diagnosis of fetal chromosomal abnormalities. Practice Bulletin No. 27Google Scholar
  11. 11.
    Christine K, Cassel. Use It or Lose It, Activity May Be the Treatment for Aging. JAMA. 2002;288:2333–2335CrossRefGoogle Scholar
  12. 12.
    Kaufert PA, Gilbert P, Tate R. Defining menopausal status: the impact of longitudinal data. Maturitas 1987;9:217–26PubMedCrossRefGoogle Scholar
  13. 13.
    Stanford JL, Hartge P, Brinton LA, Hoover RN, Brookmeyer R. Factors influencing the age at natural menopause. J Chronic Dis. 1987;40:995–1002PubMedCrossRefGoogle Scholar
  14. 14.
    van Noord-Zaadstra BM, Looman CW, Alsbach H, Habbema JD, te Velde ER, Karbaat J. Delaying childbearing: effect of age on fecundity and outcome of pregnancy. BMJ 1991;302:1361–5PubMedCrossRefGoogle Scholar
  15. 15.
    Rizk DE, Bener A, Ezimokhai M, Hassan MY, Micallef R. The age and symptomatology of natural menopause among United Arab Emirates women. Maturitas 1998;29:197–202PubMedCrossRefGoogle Scholar
  16. 16.
    Bener A, Rizk DE, Ezimokhai M, Hassan M, Micallef R, Sawaya M. Consanguinity and the age of menopause in the United Arab Emirates. Int J Gynaecol Obstet 1998;60:155–60PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science&#x002B;Business Media, Inc. 2006

Authors and Affiliations

  • Yuval Gielchinsky
    • 1
  • Moshe Mazor
    • 2
  • Alex Simon
    • 1
  • Shlomo Mor-Yossef
    • 1
  • Neri Laufer
    • 1
    Email author
  1. 1.Department of Obstetrics and GynecologyHadassah - Hebrew University Medical CenterJerusalemIsrael
  2. 2.Department of Obstetrics and GynecologySoroka University Medical Center, Ben-Gurion UniversityBeer ShevaIsrael

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