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Outcome of frozen-thawed blastocysts derived from gonadotropin releasing hormone agonist or antagonist cycles

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Abstract

Purpose: The aim of this retrospective study was to compare the outcome of frozen-thawed blastocysts derived from the cycles using controlled ovarian stimulation with GnRH agonists vs. GnRH antagonists.

Methods: Survival, pregnancy and cumulative live birth rates in 231 freeze-thaw cycles derived from the GnRH agonist cycles (GnRH agonist group), and in 175 freeze-thaw cycles derived from the GnRH antagonist cycles (GnRH antagonist group) were compared.

Results: In the GnRH agonist group significantly higher proportion of blastocysts survived the thawing procedure than in the GnRH antagonist group (86.1% versus 78.5%; p < 0.01). The differences in cumulative live birth rates did not differ significantly between the groups: in the GnRH agonist group the cumulative live birth rate was 16.5%, and in the GnRH antagonist group it was 14.2%.

Conclusions: Frozen-thawed blastocysts derived from the GnRH agonist cycles have better survival rates and similar cumulative live birth rates than those derived from the GnRH antagonist cycles.

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Acknowledgements

The authors thank all members of our IVF team for assistance in the study, to Mojca Pirc, B.A., for editing, and to Dr. Ivan Verdenik, E.E., Ph.D., for assistance with statistical analyses.

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Authors and Affiliations

  1. Reproductive Unit, Department of Obstetrics and Gynecology, University Medical Centre, Ginekoloska klinika, Slajmerjeva 3, SI-1000, Ljubljana, Slovenia

    Robert Medved, Irma Virant-Klun, Helena Meden-Vrtovec & Tomaž Tomaževič

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  1. Robert Medved
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  2. Irma Virant-Klun
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  3. Helena Meden-Vrtovec
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  4. Tomaž Tomaževič
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Correspondence to Robert Medved.

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Medved, R., Virant-Klun, I., Meden-Vrtovec, H. et al. Outcome of frozen-thawed blastocysts derived from gonadotropin releasing hormone agonist or antagonist cycles. J Assist Reprod Genet 23, 275–279 (2006). https://doi.org/10.1007/s10815-006-9051-3

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  • DOI: https://doi.org/10.1007/s10815-006-9051-3

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