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Endometrial preparation for in vitro oocyte maturation: Early use of estrogen increases endometrial tissue and requires lower daily dosage: A cross over trial in ‘mock’ cycles

  • Assisted Reproduction
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Abstract

Purpose: Determine if estrogen used since the beginning of the menstrual flow could improve endometrial tissue compared to standard endometrial preparation for in vitro maturation cycles.

Methods: Twenty polycystic ovary syndrome women were submitted to two estrogen therapy schedules: standard schedule; estrogen began on the day of planned egg retrieval (dosage was based on endometrial thickness); and long schedule; estrogen began on the first day of menstruation. No oocyte retrieval or embryo transfer was performed. Three-dimensional ultrasound was performed on the day of planned egg retrieval and one week later for endometrial evaluation.

Results: A higher endometrial thickness and volume was found in long schedule on both evaluations. The number of patients that have used 10 mg/day of estradiol was significant higher in the standard schedule (65%×0%). No other significant difference was found.

Conclusions: The early use of estrogen improves endometrial tissue and requires lower daily dosage.

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Authors and Affiliations

  1. Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Avenida dos Bandeirantes 3900, 8° Andar, CEP 14049-900, São Paulo, Brasil

    Wellington de Paula Martins, Rosana Maria dos Reis, Rui Alberto Ferriani, Carlos Henrique Medeiros de Araújo, Carolina Oliveira Nastri & Francisco Mauad Filho

  2. Escola de Ultra-sonografia de Ribeirão Preto, São Paulo, Brasil

    Wellington de Paula Martins & Francisco Mauad Filho

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  1. Wellington de Paula Martins
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  2. Rosana Maria dos Reis
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  3. Rui Alberto Ferriani
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  4. Carlos Henrique Medeiros de Araújo
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  5. Carolina Oliveira Nastri
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  6. Francisco Mauad Filho
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Correspondence to Wellington de Paula Martins.

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Martins, W.d.P., Reis, R.M.d., Ferriani, R.A. et al. Endometrial preparation for in vitro oocyte maturation: Early use of estrogen increases endometrial tissue and requires lower daily dosage: A cross over trial in ‘mock’ cycles. J Assist Reprod Genet 23, 241–246 (2006). https://doi.org/10.1007/s10815-006-9042-4

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  • DOI: https://doi.org/10.1007/s10815-006-9042-4

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