A prospective, randomized and blinded comparison between 10,000 IU urinary and 250 μg recombinant human chorionic gonadotropin for oocyte maturation in in vitro fertilization cycles
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Purpose: To compare the efficacy and safety of u-hCG with r-hCG in IVF cycles.
Methods: A prospective, investigator-blind, randomized, comparative study. Patients (n = 100) ≤ 35 years with IVF indication were randomly assigned on the day of hCG administration for oocyte maturation to receive either u-hCG (10,000 IU) or r-hCG (250 μ g).
Results: No statistical differences were found between groups in relation to total number of oocytes retrieved, percentage of mature oocytes, number of injected oocytes, fertilization rates and number of embryos transferred. The data indicate a possible trend toward a higher incidence of pregnancy in the r-hCG group. Adverse events, predominantly injection-site reactions, were significantly more common in the u-hCG group.
Conclusions: r-hCG is at least as effective for inducing final stages of oocyte maturation as 10,000 IU u-hCG and is also associated with significantly better patient tolerance and thus higher patient acceptability.
KeywordsIn vitro fertilization luteinizing hormone oocyte maturation recombinant human chorionic gonadotropin urinary human chorionic gonadotropin
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- 4.Chang P, Kenley S, Burns T, Denton G, Currie K, DeVane G, O’Dea L: Recombinant human chorionic gonadotropin (rhCG) in assisted reproductive technology: Results of a clinical trial comparing two doses of rhCG (Ovidrel) to urinary hCG (Profasi) for induction of final follicular maturation in in vitro fertilization—embryo transfer. Fertil Steril 2001;76:67–74PubMedGoogle Scholar
- 5.Driscoll GL, Tyler JP, Hangan JT, Fisher PR, Birdsall MA, Knight DC: A prospective, randomized, controlled, double-blind, double-dummy comparison of recombinant and urinary HCG for inducing oocyte maturation and follicular luteinization in ovarian stimulation. Hum Reprod 2000;15:1305–1310PubMedGoogle Scholar
- 6.The European Recombinant Human Chorionic Gonadotrophin Study Group: Induction of final follicular maturation and early luteinization in women undergoing ovulation induction for assisted reproduction treatment: Recombinant HCG versus urinary HCG. Hum Reprod 2000;15:1446–1451Google Scholar
- 7.The International Recombinant Human Chorionic Gonadotropin Study Group: Induction of ovulation in World Health Organization group II anovulatory women undergoing follicular stimulation with recombinant human follicle-stimulating hormone: A comparison of recombinant human chorionic gonadotropin (rhCG) and urinary hCG. Fertil Steril 2001;75:1111–1118Google Scholar