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Journal of Applied Spectroscopy

, Volume 84, Issue 6, pp 1030–1036 | Cite as

Optical Methods for the Analysis of the Temoprofin Photosensitizer Distribution Between Serum Proteins and Methyl-β-Cyclodextrin Nanocarriers in Blood Serum

  • I. V. Yakavets
  • I. V. Yankovsky
  • I. I. Khludeyev
  • H.P. Lassalle
  • L. N. Bezdetnaya
  • V. P. Zorin
Article

Various optical methods for the analysis of the processes leading to temoporfin photosensitizer distribution between supramolecular nanosized inclusion complexes derived from β−cyclodextrins and blood serum proteins were examined. Methods involving induced circular dichroism, fluorescence anisotropy, and the variability of the shape of the photosensitizer fluorescence excitation spectra were compared with traditional methods such as gel chromatography and ultracentrifugation. The feasibility of using the photosensitizer optical characteristics for analyzing both equilibrium and kinetic processes of photosensitizer distribution in blood was demonstrated. The main advantages and limitations of these approaches in in vitro experiments were described.

Keywords

temoporfin β-cyclodextrins inclusion complexes blood serum fluorescence anisotropy circular dichroism Soret band 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • I. V. Yakavets
    • 1
    • 2
    • 3
  • I. V. Yankovsky
    • 1
  • I. I. Khludeyev
    • 1
    • 4
  • H.P. Lassalle
    • 2
    • 3
  • L. N. Bezdetnaya
    • 2
    • 3
  • V. P. Zorin
    • 1
    • 5
  1. 1.Belarusian State UniversityMinskBelarus
  2. 2.Centre de Recherche en Automatique de NancyVandoeuvre-lès-NancyFrance
  3. 3.Institut de Cancérologie de LorraineVandoeuvre-lès-NancyFrance
  4. 4.Belarusian State University of Informatics and RadioelectronicsMinskBelarus
  5. 5.A. D. Sakharov International State Environmental Institute of the Belarusian State UniversityMinskBelarus

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