Journal of Applied Spectroscopy

, Volume 82, Issue 1, pp 98–103 | Cite as

Application of X-Ray Fluorescence Analysis to Determine the Elemental Composition of Tissues from Different Ovarian Neoplasms

  • I. G. Motevich
  • N. D. Strekal
  • N. M. Papko
  • M. I. Glebovich
  • A. V. Shulha
  • S. A. Maskevich

We present the results of x-ray fluorescence analysis of tissues from healthy ovaries and from ovaries with different pathologies: benign and borderline tumors, mucinous and endometrioid cancers, serous carcinomas. We determine the average copper, zinc, calcium, selenium, cadmium, lead, and mercury levels. We observed that in the benign ovarian tumors, we see a significant decrease in the cadmium, mercury, and lead levels compared with healthy tissues. In the borderline neoplasms, the copper level is reduced relative to zinc (Cu/Zn), cadmium, mercury, and lead, and also the zinc concentration is increased. In the ovarian carcinomas, we observed changes in the ratio of the chemical elements in the tumor tissues, depending on the histologic type. The results obtained can be used for differentiation, diagnosis, and adjustment of treatment for different ovarian neoplasms.


x-ray fluorescence analysis endometrioid cancer mucinous cancer serous carcinoma ovarian tissues microelements 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • I. G. Motevich
    • 1
  • N. D. Strekal
    • 1
  • N. M. Papko
    • 1
  • M. I. Glebovich
    • 1
  • A. V. Shulha
    • 2
  • S. A. Maskevich
    • 1
  1. 1.Janka Kupala Grodno State UniversityGrodnoBelarus
  2. 2.Grodno State Medical UniversityGrodnoBelarus

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