Journal of Applied Spectroscopy

, Volume 76, Issue 2, pp 245–249 | Cite as

Infrared spectra of proteins and lipids in human breast malignant tissues

  • I. V. Skornyakov
  • G. B. Tolstorozhev
  • V. A. Butra

IR spectroscopy methods have been adopted for investigating resected tissues of mammary glands. IR spectra of surgical material are compared with histological data. Spectra of proteins and lipids in malignant tumors are shown to be different from those in benign tumors and in tissues outside the pathologically impacted volume. Differences in the protein spectra are due to changes in the supramolecular structure because of the cleavage of intramolecular C=O⋅⋅⋅H–N H-bonds. Spectral signatures of malignant pathologies are identified.

Key words

malignant tumor IR spectrum protein lipid structure H-bond 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    K. N. Uglyanitsa, N. G. Lud, and N. K. Uglyanitsa, General Oncology. Student Aid [in Russian], Gr. GMU, Grodno (2007).Google Scholar
  2. 2.
    L. M. Ng and R. Simmons, Anal. Chem., 71, No. 12, 343R–350R (1999).CrossRefGoogle Scholar
  3. 3.
    R. K. Dukor, in: Handbook of Vibrational Spectroscopy: Applications in Life, Pharmaceutical and Natural Sciences, Vol. 5, J. M. Chalmers and P. R. Griffiths, eds., John Wiley & Sons, New York (2002), 3335–3361.Google Scholar
  4. 4.
    J. Dubois and R. A. Shaw, Anal. Chem., 76, No. 19, 360A–367A (2004).CrossRefGoogle Scholar
  5. 5.
    H. H. Mantsch, L. P. Choo-Smith, and R. A. Shaw, Vibr. Spectrosc., 30, 31–41 (2002).CrossRefGoogle Scholar
  6. 6.
    I. V. Skornyakov, G. B. Tolstorozhev, and V. A. Butra, Zh. Prikl. Spectrosk., 75, No. 3, 395–399 (2008).Google Scholar
  7. 7.
    M. V. Vol’kenshtein, Molecules and Life [in Russian], Nauka, Moscow (1965).Google Scholar
  8. 8.
    R. D. B. Fraser and T. P. MacRae, Conformations in Fibrous Proteins and Related Synthetic Polypeptides, Academic Press, New York (1973), Chap. 5.Google Scholar
  9. 9.
    L. J. Bellamy, The Infra-Red Spectra of Complex Molecules, 2nd Ed., Methuen & Co., London (1958).Google Scholar
  10. 10.
    L. J. Bellamy, Advances in Infrared Group Frequencies, Methuen, London (1968).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • I. V. Skornyakov
    • 1
  • G. B. Tolstorozhev
    • 1
  • V. A. Butra
    • 2
  1. 1.B. I. Stepanov Institute of PhysicsNational Academy of Sciences of BelarusMinskBelarus
  2. 2.Department of Oncological Morphology of the City Clinical Pathologic Anatomy BureauMinskBelarus

Personalised recommendations