Infrared spectra of proteins and lipids in human breast malignant tissues
IR spectroscopy methods have been adopted for investigating resected tissues of mammary glands. IR spectra of surgical material are compared with histological data. Spectra of proteins and lipids in malignant tumors are shown to be different from those in benign tumors and in tissues outside the pathologically impacted volume. Differences in the protein spectra are due to changes in the supramolecular structure because of the cleavage of intramolecular C=O⋅⋅⋅H–N H-bonds. Spectral signatures of malignant pathologies are identified.
Key wordsmalignant tumor IR spectrum protein lipid structure H-bond
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- 1.K. N. Uglyanitsa, N. G. Lud, and N. K. Uglyanitsa, General Oncology. Student Aid [in Russian], Gr. GMU, Grodno (2007).Google Scholar
- 3.R. K. Dukor, in: Handbook of Vibrational Spectroscopy: Applications in Life, Pharmaceutical and Natural Sciences, Vol. 5, J. M. Chalmers and P. R. Griffiths, eds., John Wiley & Sons, New York (2002), 3335–3361.Google Scholar
- 6.I. V. Skornyakov, G. B. Tolstorozhev, and V. A. Butra, Zh. Prikl. Spectrosk., 75, No. 3, 395–399 (2008).Google Scholar
- 7.M. V. Vol’kenshtein, Molecules and Life [in Russian], Nauka, Moscow (1965).Google Scholar
- 8.R. D. B. Fraser and T. P. MacRae, Conformations in Fibrous Proteins and Related Synthetic Polypeptides, Academic Press, New York (1973), Chap. 5.Google Scholar
- 9.L. J. Bellamy, The Infra-Red Spectra of Complex Molecules, 2nd Ed., Methuen & Co., London (1958).Google Scholar
- 10.L. J. Bellamy, Advances in Infrared Group Frequencies, Methuen, London (1968).Google Scholar