Journal of Applied Spectroscopy

, Volume 74, Issue 1, pp 133–139 | Cite as

Kinetics of oxygenation of skin tissue exposed to low-intensity laser radiation

  • M. M. Asimov
  • A. N. Korolevich
  • E. É. Konstantinova


We present the results of modeling the action spectrum and an experimental investigation of the effect of laser-induced photodissociation of oxyhemoglobin in vivo on the increase in the degree of oxygenation of skin tissue in the exposed area. We have shown that controlling the local concentration of free molecular oxygen in biological tissues together with the possibility of eliminating tissue hypoxia using laser radiation makes it possible to stimulate aerobic cell metabolism and to achieve the needed therapeutic effect.

Key words

oxyhemoglobin tissue oxygenation transcutaneous oximetry photodissociation low-intensity laser radiation 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    G. Anneroth, G. Hall, H. Ryden, Zetterqist, Brit. J. Oral Maxillofacial Surg., 26, 12–17 (1988).CrossRefGoogle Scholar
  2. 2.
    J. S. Kana, G. Hutschenrieter, D. Haina, and W. Waidelich, Arch. Surg., 116, 293–296 (1984).Google Scholar
  3. 3.
    J. D. Whitney, Heart and Lung, 18, 466–474 (1989).MathSciNetGoogle Scholar
  4. 4.
    R. A. Abergel, R. F. Lyons, J. C. Castel et al., Dermatol. Surg. Oncol., 13, 127–133 (1987).Google Scholar
  5. 5.
    J. Fuchs and J. Thiele, Free Radic. Biol. Med., 15, 835–847 (1998).CrossRefGoogle Scholar
  6. 6.
    I. Georgakoudi, M. G. Nichols, and T. H. Foster, Photochem. Photobiol., 65, 135–144 (1997).Google Scholar
  7. 7.
    B. M. Dzhagarov, E. A. Zhavrid, Yu. P. Istomin, and V. N. Chalov, Zh. Prikl. Spektr., 68, 151–153 (2001).Google Scholar
  8. 8.
    P. S. Grim, JAMA, 263, 2216–2220 (1990).CrossRefGoogle Scholar
  9. 9.
    S. N. Efuni, Handbook on Hyperbaric Oxygenation [in Russian], Meditsina, Moscow (1986).Google Scholar
  10. 10.
    M. M. Asimov, R. M. Asimov, and A. N. Rubinov, in: Proceedings of the Third Conference on Laser Physics and Spectroscopy, Grodno, 2–4 July 1997 [in Russian], Institute of Physics, National Academy of Sciences of Belarus, Minsk (1997), pp. 169–172.Google Scholar
  11. 11.
    M. M. Asimov, R. M. Asimov, and A. N. Rubinov, Zh. Prikl. Spektr., 65, 919–922 (1998).Google Scholar
  12. 12.
    B. M. Dzhagarov, V. A. Galievskii, N. N. Kruk, and M. D. Yakutovich, Dokl. Ross. Akad. Nauk, 366, No. 1, 121–124 (1999).Google Scholar
  13. 13.
    M. M. Asimov, R. M. Asimov, and A. N. Rubinov, Proc. SPIE, 3254, 407–412 (1998).CrossRefADSGoogle Scholar
  14. 14.
    R. R. Anderson and J. A. Parrish, J. Invest. Dermatol., 77, 13–19 (1981).CrossRefGoogle Scholar
  15. 15.
    M. M. Asimov, R. M. Asimov, A. N. Rubinov, S. A. Mamilov, and Yu. S. Plaksii, Zh. Prikl. Spektr., 73, 90–93 (2006).Google Scholar
  16. 16.
    M. Asimov, R. Asimov, M. Mirshahi, and A. Gizbrecht, Proc. SPIE, 4397, 390–394 (2001).CrossRefADSGoogle Scholar
  17. 17.
    M. M. Asimov, R. M. Asimov, S. A. Mamilov, Yu. S. Plaksiy, A. N. Rubinov, and A. I. Gisbrecht, Proc. SPIE, 5830, 409–413 (2005).CrossRefADSGoogle Scholar
  18. 18.
    L. A. Marsagashvili, Ts. I. Urushadze, G. A. Donadze, T. V. Bedenashvili, and G. V. Apakidze, Lazernaya Meditsina, 7, 23–27 (2003).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • M. M. Asimov
    • 1
  • A. N. Korolevich
    • 1
  • E. É. Konstantinova
    • 2
  1. 1.B. I. Stepanov Institute of PhysicsNational Academy of Sciences of BelarusMinsk
  2. 2.National Research and Medical Center for CardiologyMinistry of HealthMinskRepublic of Belarus

Personalised recommendations