Oxidative stress biomarkers in organs of hyperlipidaemic and normal rats fed tropical red seaweed, Gracilaria changii
The aim of the study was to evaluate the effects of normal and high-cholesterol/fat diet supplemented with 5 and 10 % freeze-dried red seaweed, Gracilaria changii powder on rat organs (liver, kidney and heart), lipid peroxidation and antioxidant enzyme activities. The results showed that feeding with atherogenic diet alone caused lipid peroxidation which eventually leads to oxidative stress of the rat’s organs. Nevertheless, with 10 % G. changii supplementation, it significantly decreased the liver lipid peroxidation by 52.24 %, and the antioxidant enzyme activities were significantly increased by 52.09 to 94.42 %. Similarly, with G. changii supplementation, it significantly enhanced the kidney antioxidant enzyme activities. This suggests that G. changii suppress oxidative stress and protect the rats’ organs. In conclusion, G. changii could be a promising functional food ingredient in the management of hyperlipidaemia.
KeywordsLipid peroxidation Enzymes antioxidants Hyperlipidaemic Red seaweed
The authors thank the Fisheries Research Institute Malaysia Sarawak and the Seaweed Research Unit at Universiti Malaysia Sabah for supplying the seaweed. This study was funded by the Ministry of Science, Technology and Innovation of Malaysia (MOSTI), Project code: 06-01-10-SF0163.
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