This study aimed to investigate the role of leptin, ghrelin, neuropeptide Y, and nesfatin-1 in young children with autism spectrum disorder (ASD). A total of 44 children with ASD and 44 healthy controls aged 18–60 months were included. Plasma levels of hormones were measured using commercial enzyme-linked immunosorbent assay kits. Plasma leptin and ghrelin levels were significantly higher in the ASD group than in the control group. However, no significant difference for plasma neuropeptide Y and nesfatin-1 levels was detected between the groups. No relation was found between the severity of ASD symptoms, severity of eating problems, and plasma levels of hormones. Leptin and ghrelin may play a potential role in the pathogenesis of ASD.
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The authors wish to thank the patients and families who participated in this study. This study adapted from the dissertation of Dr. Çağla Çelikkol Sadıç.
Funding for this study was provided by a grant from the Scientific Research Project Coordination Unit of Necmettin Erbakan University (Project No: 181518012).
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The authors report no conflicts of interest.
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Çelikkol Sadıç, Ç., Bilgiç, A., Kılınç, İ. et al. Evaluation of Appetite-Regulating Hormones ın Young Children with Autism Spectrum Disorder. J Autism Dev Disord 51, 632–643 (2021). https://doi.org/10.1007/s10803-020-04579-0
- Neuropeptide Y
- Early childhood