Deviations from Typical Developmental Trajectories Detectable at 9 Months of Age in Low Risk Children Later Diagnosed with Autism Spectrum Disorder
This study was designed to track the developmental trajectory, during the first 24 months of life, of 335 low-risk infants later diagnosed with Autism Spectrum Disorder and identify early deviations observed in routine Well Care checkups. We compared their achievements to typically developing children and to children later diagnosed with non-autistic developmental impairments. The results show that in the first 6 months, the children with autism showed normal acquisition of milestones, whereas by 9 months of age they began to fail the language/communication, as well as motor items when compared to typical and delayed non-autistic children. Regular check-up visits may be useful in detecting early failure in achieving milestones, leading to earlier referral for further evaluation and treatment.
KeywordsAutism spectrum disorder Early development Developmental trajectories Low risk
The authors thank Lior Ganor and Diana Kogan for editing the manuscript.
MD made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data and was involved in drafting the manuscript. NS made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data. GK made substantial contributions to analysis and interpretation of data, and was involved and revising it critically for important intellectual content. BCF made substantial contributions to analysis and interpretation of data and was involved in drafting the manuscript.
Compliance with Ethical Standards
Conflict of interest
All authors are employees of Maccabi Healthcare Services.
The study was approved by the Ethics Review Board of Maccabi Healthcare Services.
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