Mismatch Negativity and P3a in Adolescents and Young Adults with Autism Spectrum Disorders: Behavioral Correlates and Clinical Implications
In a sample of 37 adolescents and young adults with autism spectrum disorder (ASD) and 35 typically-developing controls (TDC), we investigated sensory symptoms by clinical measures, and Mismatch Negativity and P3a component at Fz with the frequency and duration oddball paradigms of event-related potentials. Results showed that compared to TDC, ASD participants reported more sensory symptoms, and presented a shorter P3a peak latency in the duration paradigm, which was correlated with more social awareness deficits. In the frequency paradigm, P3a parameters were correlated with sensation avoiding and attention characteristics of ASD. Our findings suggest that sensory abnormality in ASD may extend into adolescence and young adulthood. P3a latency might be a potential neurophysiological marker for ASD.
KeywordsAutism spectrum Event-related potentials Mismatch negativity P3a Correlates
This work was supported by grants from National Science Council (NSC96-3112-B-002-033; NSC97-3112-B-002-009; NSC98-3112-B-002-004; NSC 101-2314-B-002-136-MY3), and National Taiwan University Hospital (NTUH100-M001743, NTUH104-M2886), Taiwan.
YC conceived of the study, participated in its design and coordination, collected the sample, analyzed the data and drafted the manuscript; MH performed the event-related potentials measurement, participated in the data analysis and interpretation; SG participated in the design and coordination of the study, confirmed the clinical diagnosis, supervised the statistical analysis and data interpretation, and did rigorous revision on the manuscript. All authors read and approved the final manuscript.
Compliance with Ethical Standards
Conflict of interest
The authors declare no competing financial interests.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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