Journal of Autism and Developmental Disorders

, Volume 45, Issue 7, pp 2187–2199 | Cite as

Diary Reports of Concerns in Mothers of Infant Siblings of Children with Autism Across the First Year of Life

  • Meagan R. Talbott
  • Charles A. Nelson
  • Helen Tager-Flusberg
Original Paper


We examined the home-based concerns reported by mothers of infant siblings of children with autism across the first year of life. At all three ages measured, mothers of high-risk infants were significantly more likely than mothers of low-risk infants to report language, social communication, and restricted and repetitive behavior concerns but were not more likely to report general, medically based concerns. At 6 and 9 months of age, maternal concerns were poorly related to infant or family variables. At 12 months of age, there were moderate correlations between maternal concerns and infant behavior, and concerns were associated with the proband’s autism symptoms and mothers’ concurrent depressive symptoms. These findings highlight the need to examine high-risk infants’ development in the family context.


High risk infant siblings Parental concerns Autism Home-based measures 



We are extremely grateful to the many children and families who have participated in this study, and to the project staff and interns who have assisted in the data collection, especially Karen Chenausky. This work was supported by grants from the NIH (R01-DC010290 and R21 DC 08637), Autism Speaks, and the Simons Foundation (137186).


  1. Bailey, D. B., Golden, R. N., Roberts, J., & Ford, A. (2007). Maternal depression and developmental disability: Research critique. Mental Retardation and Developmental Disabilities Research Reviews, 13, 321–329. doi: 10.1002/mrdd.PubMedCrossRefGoogle Scholar
  2. Bennett, T., Boyle, M., Georgiades, K., Georgiades, S., Thompson, A., Duku, E., & Szatmari, P. (2012). Influence of reporting effects on the association between maternal depression and child autism spectrum disorder behaviors. Journal of Child Psychology and Psychiatry and Allied Disciplines, 53(1), 89–96. doi: 10.1111/j.1469-7610.2011.02451.x.CrossRefGoogle Scholar
  3. Bryson, S. E., McDermott, C., Rombaugh, V., Brian, J., & Zwaigenbaum, L. (2000). The autism observation scale for infants. Toronto, ON: Unpublished Scale.Google Scholar
  4. Chawarska, K., Paul, R., Klin, A., Hannigen, S., Dichtel, L. E., & Volkmar, F. (2007). Parental recognition of developmental problems in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37(1), 62–72. doi: 10.1007/s10803-006-0330-8.PubMedCrossRefGoogle Scholar
  5. Daniels, J. L., Forssen, U., Hultman, C. M., Cnattingius, S., Savitz, D. A., Feychting, M., & Sparen, P. (2008). Parental psychiatric disorders associated with autism spectrum disorders in the offspring. Pediatrics, 121(5), e1357–e1362. doi: 10.1542/peds.2007-2296.PubMedCrossRefGoogle Scholar
  6. De Giacomo, A., & Fombonne, E. (1998). Parental recognition of developmental abnormalities in autism. European Child and Adolescent Psychiatry, 7(3), 131–136.PubMedCrossRefGoogle Scholar
  7. Eaton, W. W., Smith, C., Ybarra, M., Muntaner, C., & Tien, A. (2004). Center for epidemiologic studies depression scale: Review and revision (CESD and CESD-R). In M. E. Maruish (Ed.), The use of psychological testing for treatment planning and outcomes assessment, instruments for adults (3rd ed., pp. 363–377). Mahwah, NJ.: Lawrence Erlbuam Associates Publishers.Google Scholar
  8. Estes, A., Munson, J., Dawson, G., Koehler, E., Zhou, X.-H., & Abbott, R. (2009). Parenting stress and psychological functioning among mothers of preschool children with autism and developmental delay. Autism: The International Journal of Research and Practice, 13(4), 375–387. doi: 10.1177/1362361309105658.CrossRefGoogle Scholar
  9. Fergusson, D. M., Lynskey, M. T., & Horwood, L. J. (1993). The effect of maternal depression on maternal ratings of child behavior. Journal of Abnormal Child Psychology, 21(3), 245–269. doi: 10.1007/BF00917534.PubMedCrossRefGoogle Scholar
  10. Gamliel, I., Yirmiya, N., Jaffe, D. H., Manor, O., & Sigman, M. (2009). Developmental trajectories in siblings of children with autism: Cognition and language from 4 months to 7 ears. Journal of Autism and Developmental Disorders, 39(8), 1131–1144. doi: 10.1007/s10803-009-0727-2.PubMedCentralPubMedCrossRefGoogle Scholar
  11. Herlihy, L., Knoch, K., Vibert, B., & Fein, D. (2013). Parents’ first concerns about toddlers with autism spectrum disorder: Effect of sibling status. Autism. doi: 10.1177/1362361313509731.PubMedGoogle Scholar
  12. Hess, C. R., & Landa, R. J. (2012). Predictive and concurrent validity of parent concern about young children at risk for autism. Journal of Autism and Developmental Disorders, 42(4), 575–584. doi: 10.1007/s10803-011-1282-1.PubMedCentralPubMedCrossRefGoogle Scholar
  13. Holm, S. (1979). a simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics, 6(2), 65–70.Google Scholar
  14. Ingersoll, B., & Hambrick, D. Z. (2011). The relationship between the broader autism phenotype, child severity, and stress and depression in parents of children with autism spectrum disorders. Research in Autism Spectrum Disorders, 5(1), 337–344. doi: 10.1016/j.rasd.2010.04.017.CrossRefGoogle Scholar
  15. Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., & Rutter, M. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.PubMedCrossRefGoogle Scholar
  16. Maoz, H., Goldstein, T., Goldstein, B. I., Axelson, D. A., Fan, J., Hickey, M. B., & Birmaher, B. (2014). The effects of parental mood on reports of their children’s psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry, 53(10), 1111–1122. doi: 10.1016/j.jaac.2014.07.005. e5.PubMedCrossRefGoogle Scholar
  17. Mitchell, S., Brian, J., Zwaigenbaum, L., Roberts, W., Szatmari, P., Smith, I., & Bryson, S. (2006). Early language and communication development of infants later diagnosed with autism spectrum disorder. Journal of Developmental and Behavioral Pediatrics, 27, S69–S78. doi: 10.1097/00004703-200604002-00004.PubMedCrossRefGoogle Scholar
  18. Mullen, E. M. (1995). The Mullen scales of early learning: AGS edition manual. Circle Pines, MN: AGS.Google Scholar
  19. Munson, J., Dawson, G., Sterling, L., Beauchaine, T., Zhou, A., Koehler, E., & Abbott, R. (2008). Evidence for latent classes of IQ in young children with autism spectrum disorder. Journal Information, 113(6), 439–452. doi: 10.1352/2008.113.Google Scholar
  20. Osterling, J., & Dawson, G. (1994). Early recognition of children with autism: A study of first birthday home videotapes. Journal of Autism and Developmental Disorders, 24(3), 247–257. doi: 10.1007/BF02172225.PubMedCrossRefGoogle Scholar
  21. Ozonoff, S., Iosif, A.-M., Young, G. S., Hepburn, S., Thompson, M., Colombi, C., & Rogers, S. J. (2011a). Onset patterns in autism: Correspondence between home video and parent report. Journal of the American Academy of Child and Adolescent Psychiatry, 50(8), 796–806. doi: 10.1016/j.jaac.2011.03.012. e1.PubMedCentralPubMedCrossRefGoogle Scholar
  22. Ozonoff, S., Losif, A.-M., Baguio, F., Cook, I. C., Hill, M. M. M., Hutman, T., & Young, G. S. (2010). A prospective study of the emergence of early behavioral signs of autism. Journal of the American Academy of Child and Adolescent Psychiatry, 49(3), 256–266. doi: 10.1097/00004583-201003000-00009.PubMedCentralPubMedGoogle Scholar
  23. Ozonoff, S., Young, G. S., Belding, A., Hill, M., Hill, A., Hutman, T., & Iosif, A.-M. (2014). The broader autism phenotype in infancy: When does it emerge? Journal of the American Academy of Child and Adolescent Psychiatry, 53(4), 398–407. doi: 10.1016/j.jaac.2013.12.020. e2.PubMedCentralPubMedCrossRefGoogle Scholar
  24. Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., & Stone, W. L. (2011b). Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics, 128(3), e488–e495. doi: 10.1542/peds.2010-2825.PubMedCentralPubMedGoogle Scholar
  25. Ozonoff, S., Young, G., Steinfeld, M., Hill, M. M., Cook, I., Hutman, T., & Sigman, M. (2009). How early do parent concerns predict later autism diagnosis? Journal of Developmental and Behavioral Pediatrics, 30(5), 367–375.PubMedCentralPubMedCrossRefGoogle Scholar
  26. Pan, B. A., Rowe, M. L., Singer, J. D., & Snow, C. E. (2005). Maternal correlates of growth in toddler vocabulary production in low-income families. Child Development, 76, 763–782. doi: 10.1111/j.1467-8624.2005.00876.x.PubMedGoogle Scholar
  27. Rowberry, J., Macari, S., Chen, G., Campbell, D., Leventhal, J. M., Weitzman, C., & Chawarska, K. (2014). Screening for autism spectrum disorders in 12-month-old high-risk siblings by parental report. Journal of Autism and Developmental Disorders. doi: 10.1007/s10803-014-2211-x.Google Scholar
  28. Rowe, M. L., Pan, B. A., & Ayoub, C. (2005). Predictors of variation in maternal talk to children: A longitudinal study of low-income families. Parenting: Science and Practice, 5(3), 259–283. doi: 10.1207/s15327922par0503_3.CrossRefGoogle Scholar
  29. Rutter, M., Bailey, A., & Lord, C. (2003). Social communication questionnaire. Los Angeles, CA: Western Psychological Services.Google Scholar
  30. Saint-Georges, C., Mahdhaoui, A., Chetouani, M., Cassel, R. S., Laznik, M.-C., Apicella, F., & Cohen, D. (2011). Do parents recognize autistic deviant behavior long before diagnosis? Taking into account interaction using computational methods. PLoS One, 6(7), e22393. doi: 10.1371/journal.pone.0022393.PubMedCentralPubMedCrossRefGoogle Scholar
  31. Talbott, M. R., Nelson, C. A., & Tager-Flusberg, H. (2013). Maternal gesture use and language development in infant siblings of children with autism spectrum disorder. Journal of Autism and Developmental Disorders. doi: 10.1007/s10803-013-1820-0.Google Scholar
  32. Veness, C., Prior, M., Bavin, E., Eadie, P., Cini, E., & Reilly, S. (2012). Early indicators of autism spectrum disorders at 12 and 24 months of age: A prospective, longitudinal comparative study. Autism: The International Journal of Research and Practice, 16(2), 163–177. doi: 10.1177/1362361311399936.CrossRefGoogle Scholar
  33. Wan, M. W., Green, J., Elsabbagh, M., Johnson, M., Charman, T., & Plummer, F. (2013). Quality of interaction between at-risk infants and caregiver at 12–15 months is associated with 3-year autism outcome. Journal of Child Psychology and Psychiatry and Allied Disciplines, 54(7), 763–771. doi: 10.1111/jcpp.12032.CrossRefGoogle Scholar
  34. Wan, M. W., Green, J., Elsabbagh, M., Johnson, M., Charman, T., Plummer, F., & Tucker, L. (2012). Parent–infant interaction in infant siblings at risk of autism. Research in Developmental Disabilities, 33(3), 924–932. doi: 10.1016/j.ridd.2011.12.011.PubMedCrossRefGoogle Scholar
  35. Werner, E., Dawson, G., Osterling, J., & Dinno, N. (2000). Brief report: Recognition of autism spectrum disorder before one year of age: A retrospective study based on home videotapes. Journal of Autism and Developmental Disorders, 30(2), 157–162. doi: 10.1023/A:1005463707029.PubMedCrossRefGoogle Scholar
  36. Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005). Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neuroscience, 23, 143–152. doi: 10.1016/j.ijdevneu.2004.05.001.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Meagan R. Talbott
    • 1
    • 4
  • Charles A. Nelson
    • 2
    • 3
  • Helen Tager-Flusberg
    • 4
  1. 1.MIND InstituteUniversity of California, DavisSacramentoUSA
  2. 2.Laboratories of Cognitive Neuroscience, Division of Developmental MedicineBoston Children’s HospitalBostonUSA
  3. 3.Harvard Medical SchoolBostonUSA
  4. 4.Department of Psychological and Brain SciencesBoston UniversityBostonUSA

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